A -catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors

A new mathematical model for relative quantification in real-time RT-PCR

2001 • 32,396 citations

Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

2002 • 7,125 citations

Wnt signaling and cancer

2000 • 3,215 citations

Caught up in a Wnt storm: Wnt signaling in cancer

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Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

The PAS Superfamily: Sensors of Environmental and Developmental Signals

2000 • 1,030 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

β-catenin signaling and cancer

1999 • 867 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

2001 • 567 citations

Tumor-specific expression of cytochrome P450 CYP1B1.

1997 • 527 citations

The Wnt signaling pathway and its role in tumor development

2003 • 521 citations

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

2000 • 447 citations

New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

2002 • 386 citations

Regulation, Function, and Tissue-Specific Expression of Cytochrome P450 CYP1B1

2001 • 314 citations

TCF/LEF factors earn their wings

1997 • 288 citations

β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection

1999 • 275 citations

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

2000 • 260 citations

Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis.

2000 • 241 citations

Identification and characterization of genes associated with human hepatocellular carcinogenesis.

1999 • 230 citations

Nuclear receptor regulation of hepatic function

2002 • 169 citations

The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1996 • 164 citations

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of β-catenin-mutated mouse liver tumors

2001 • 159 citations

Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.

1991 • 157 citations

Adenomatous Polyposis Coli (APC)-independent Regulation of β-Catenin Degradation via a Retinoid X Receptor-mediated Pathway

2003 • 144 citations

Genetic alterations in hepatoblastoma and hepatocellular carcinoma: Common and distinctive aspects

2002 • 142 citations

Aryl hydrocarbon or dioxin receptor: Biologic and toxic responses

1993 • 137 citations

Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver

1985 • 135 citations

Constitutive expression of hepatic cytochrome P450 genes

1996 • 126 citations

Transcriptional Activation of Interleukin-8 by β-Catenin-Tcf4

2002 • 125 citations

Mutation of β-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis

1999 • 125 citations

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.

2002 • 120 citations

A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.

1976 • 118 citations

Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors

2003 • 117 citations

Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of β-catenin in the liver

2004 • 111 citations

Gene Expression Profile Analysis in Human Hepatocellular Carcinoma by cDNA Microarray

2002 • 104 citations

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.

2001 • 94 citations

Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital. Differences in structure and in the metabolism of alkoxyresorufins

1986 • 90 citations

p53 mutations are absent from carcinogen‐induced mouse liver tumors but occur in cell lines established from these tumors

1992 • 86 citations

Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.

2000 • 82 citations

Colocalized alterations in connexin32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters.

1994 • 65 citations

Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.

1982 • 65 citations

Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer

1998 • 64 citations

Activation of β-catenin provides proliferative and invasive advantages in c-myc /TGF-α hepatocarcinogenesis promoted by phenobarbital

2004 • 51 citations

Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of ha-ras oncogenes

1997 • 48 citations

Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of β-catenin and synergistic effect of p53 null alleles

2000 • 48 citations

Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures11Abbreviations: CYP, cytochrome P450; EGF, epidermal growth factor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MC, methylcholanthrene; PB, phenobarbital; PBO, piperonyl butoxide; PBREM, phenobarbital-responsive enhancer module; and PROD, pentoxyresorufin-O-depentylase.

2001 • 43 citations

Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.

1987 • 42 citations

Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions

1998 • 37 citations

Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization

1987 • 33 citations

High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas

1993 • 32 citations

Role of Connexin32 and β-Catenin in Tumor Promotion in Mouse Liver

2003 • 27 citations

Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcinogenesis

1987 • 26 citations

Residue Threonine 350 Confers Steroid Hormone Responsiveness to the Mouse Nuclear Orphan Receptor CAR

2002 • 22 citations

Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.

1998 • 21 citations

Wild-type function of the p53 tumor suppressor protein is not required for apoptosis of mouse hepatoma cells

1998 • 21 citations

p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ betweenRas-mutated andRas-wild-type lesions

1998 • 20 citations

Role of Connexin32 and beta-Catenin in Tumor Promotion in Mouse Liver

2003 • 16 citations

Enzyme and immunohistochemical phenotyping of diethylnitrosamine-induced liver lesions of male C3H/He, B6C3F1 and C57BL/6J mice

1992 • 10 citations

Cytochrome P450 1B1 expression in human malignant tumours

1996 • 6 citations