Adenomatous Polyposis Coli (APC)-independent Regulation of β-Catenin Degradation via a Retinoid X Receptor-mediated Pathway

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling and cancer

2000 • 3,215 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

The promise of retinoids to fight against cancer

2001 • 763 citations

A common human skin tumour is caused by activating mutations in β-catenin

1999 • 608 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

2001 • 416 citations

β-Catenin—A Linchpin in Colorectal Carcinogenesis?

2002 • 340 citations

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

2000 • 332 citations

Retinoids and their receptors in cancer development and chemoprevention

2002 • 321 citations

Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.

2003 • 294 citations

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

2000 • 265 citations

Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the β-catenin gene

2001 • 233 citations

Cross-regulation of β-catenin–LEF/TCF and retinoid signaling pathways

1999 • 232 citations

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

2001 • 209 citations

The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

2002 • 185 citations

Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis

2002 • 182 citations

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

2001 • 164 citations

Dimerization with Retinoid X Receptors and Phosphorylation Modulate the Retinoic Acid-induced Degradation of Retinoic Acid Receptors α and γ through the Ubiquitin-Proteasome Pathway

2000 • 152 citations

Casein Kinase 1: A Wnt'er of Disconnect

2002 • 152 citations

One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

1987 • 127 citations

More Than One Way to Skin a Catenin

2001 • 103 citations

Nuclear Receptor Coactivators

1999 • 102 citations

Identification of Gene-selective Modulators of the Bile Acid Receptor FXR

2003 • 100 citations

β‐Catenin gene mutation in human hair follicle‐related tumors

2001 • 95 citations

Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells.

2001 • 94 citations

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1995 • 85 citations

Synergistic Induction of Tumor Antigens by Wnt-1 Signaling and Retinoic Acid Revealed by Gene Expression Profiling

2002 • 72 citations

Enantioselective Syntheses of Potent Retinoid X Receptor Ligands: Differential Biological Activities of Individual Antipodes

2001 • 67 citations

β-Catenin Antisense Treatment Decreases β-Catenin Expression and Tumor Growth Rate in Colon Carcinoma Xenografts

2001 • 64 citations

Retinoid-dependent Recruitment of a Histone H1 Displacement Activity by Retinoic Acid Receptor

1999 • 56 citations

Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions

2001 • 55 citations

Activation of the β-Catenin/Lef-Tcf Pathway Is Obligate for Formation of Primitive Endoderm by Mouse F9 Totipotent Teratocarcinoma Cells in Response to Retinoic Acid

2002 • 51 citations

Synthesis and biological activity of high-affinity retinoic acid receptor antagonists

1999 • 45 citations

Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells.

2001 • 44 citations

Estrogen Induces Retinoid Receptor Expression in Mouse Cervical Epithelia

1996 • 22 citations