Neural Basis for the Hyperalgesic Action of Cholecystokinin in the Rostral Ventromedial Medulla

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Neurotransmitters in Nociceptive Modulatory Circuits

1991 • 970 citations

Chronic pain and medullary descending facilitation

2002 • 968 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Supraspinal contributions to hyperalgesia

1999 • 512 citations

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat

1983 • 499 citations

An analgesia circuit activated by cannabinoids

1998 • 412 citations

Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain

2002 • 343 citations

Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

2001 • 337 citations

Anatomy and physiology of a nociceptive modulatory system

1985 • 287 citations

Opioid-induced hyperalgesia: abnormal or normal pain?

2003 • 270 citations

The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat

1990 • 270 citations

Potentiation of Opiate Analgesia and Apparent Reversal of Morphine Tolerance by Proglumide

1984 • 269 citations

Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin

2001 • 269 citations

Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla

1994 • 267 citations

Textbook of Pain, 4th ed

2001 • 261 citations

Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor

2001 • 259 citations

Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers

2002 • 252 citations

Direct and indirect actions of morphine on medullary neurons that modulate nociception

1992 • 235 citations

Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat

2000 • 209 citations

Opioid actions on single nucleus raphe magnus neurons from rat and guinea‐pig in vitro.

1990 • 202 citations

Acute tolerance associated with a single opiate administration: involvement of N-methyl-d-aspartate-dependent pain facilitatory systems

1998 • 190 citations

Putative Nociceptive Modulating Neurons in the Rostral Ventromedial Medulla of the Rat: Firing of On- and Off-Cells Is Related to Nociceptive Responsiveness

1989 • 184 citations

Hyperalgesia during Naloxone-Precipitated Withdrawal from Morphine Is Associated with Increased On-Cell Activity in the Rostral Ventromedial Medulla

1990 • 181 citations

Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide

1985 • 156 citations

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

2003 • 150 citations

Cholecystokinin Antianalgesia: Safety Cues Abolish Morphine Analgesia

1992 • 138 citations

Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates

1985 • 136 citations

Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil

1996 • 135 citations

Nociceptive facilitating neurons in the rostral ventromedial medulla

2004 • 133 citations

Circuitry Underlying Antiopioid Actions of Cholecystokinin Within the Rostral Ventromedial Medulla

2001 • 126 citations

Capsaicin Infused Into the PAG Affects Rat Tail Flick Responses to Noxious Heat and Alters Neuronal Firing in the RVM

2003 • 116 citations

A Neuronal Correlate of Secondary Hyperalgesia in the Rat Spinal Dorsal Horn Is Submodality Selective and Facilitated by Supraspinal Influence

1998 • 109 citations

Regulation of morphine antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats.

1995 • 107 citations

Cholecystokinin antianalgesia: safety cues abolish morphine analgesia

1992 • 103 citations

Putative Nociceptive Modulatory Neurons in the Rostral Ventromedial Medulla of the Rat Display Highly Correlated Firing Patterns

1989 • 97 citations

Cholecystokinin as a factor in the enhanced potency of spinal morphine following carrageenin inflammation

1993 • 96 citations

Morphine-induced analgesia in the rat paw pressure test is blocked by CCK and enhanced by the CCK antagonist MK-329

1989 • 85 citations

A locus and mechanism of action for associative morphine tolerance

2000 • 84 citations

Chronic pain-related behaviors in spinally injured rats: Evidence for functional alterations of the endogenous cholecystokinin and opioid systems

1994 • 83 citations

Cholecystokinin/opioid interactions

1999 • 82 citations

The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine

1999 • 81 citations

The contribution of the rostral ventromedial medulla to the antinociceptive effects of systemic morphine in restrained and unrestrained rats

1998 • 75 citations

Supraspinal Influence on Hindlimb Withdrawal Thresholds and Mustard Oil-Induced Secondary Allodynia in Rats

1997 • 70 citations

Involvement of local cholecystokinin in the tolerance induced by morphine microinjections into the periaqueductal gray of rats

2003 • 64 citations

Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry

1998 • 63 citations

The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats

1994 • 60 citations

Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat

1989 • 60 citations

The CCK-A and CCK-B receptor antagonists, devazepide and L-365,260, enhance morphine antinociception only in non-acclimated rats exposed to a novel environment

1992 • 57 citations

Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses

1993 • 56 citations

Tooth pulp stimulation advances both medullary off-cell pause and tail flick

1989 • 49 citations

Effects of spinal cholecystokinin receptor antagonists on morphine antinociception in a model of visceral pain in the rat.

2000 • 48 citations

Modulation of visceral hyperalgesia by morphine and cholecystokinin from the rat rostroventral medial medulla

2003 • 46 citations

The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry

1994 • 40 citations

Differential release of cholecystokinin by morphine in rat spinal cord

1998 • 39 citations

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

2003 • 37 citations

Delta opioid receptor mediated actions in the rostral ventromedial medulla on tail flick latency and nociceptive modulatory neurons

2000 • 35 citations

Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins

1996 • 34 citations

Spinal effect of the cholecystokinin-B receptor antagonist CI-988 on hyperalgesia, allodynia and morphine-induced analgesia in diabetic and mononeuropathic rats

2000 • 33 citations

Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat

1995 • 32 citations

Cholecystokinin octapeptide (CCK-8) antagonizes morphine analgesia in nucleus accumbens of the rat via the CCK-B receptor

1994 • 27 citations

Opposing actions of norepinephrine and clonidine on single pain-modulating neurons in rostral ventromedial medulla

1987 • 25 citations

Differential effects of the CCK antagonist, MK-329, on analgesia induced by morphine, social conflict (opioid) and defeat experience (non-opioid) in male mice

1989 • 22 citations

Pharmacological Characterization of Morphine‐Induced In Vivo Release of Cholecystokinin in Rat Dorsal Horn

1999 • 20 citations

The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice

2001 • 20 citations

Stress reduces morphine's antinociceptive potency: dependence upon spinal cholecystokinin processes

1999 • 19 citations

Potentiation of morphine and clomipramine analgesia by cholecystokinin -B antagonist CI-988 in diabetic rats

2000 • 18 citations

CCKB receptors in the periaqueductal grey are involved in electroacupuncture antinociception in the rat cold water tail-flick test

1998 • 17 citations

Electrophysiological studies on the spinal roles of endogenous opioids in carrageenan inflammation

1994 • 17 citations

Extracellular cholecystokinin levels in the rat spinal cord following chronic morphine exposure: an in vivo microdialysis study

1999 • 13 citations