Capsaicin Infused Into the PAG Affects Rat Tail Flick Responses to Noxious Heat and Alters Neuronal Firing in the RVM

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

1998 • 3,026 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

1991 • 2,139 citations

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1999 • 2,128 citations

Vanilloid (Capsaicin) receptors and mechanisms.

1999 • 1,825 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

2000 • 1,048 citations

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

2002 • 959 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Functional characteristics of the midbrain periaqueductal gray

1995 • 855 citations

Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X₃ purinoceptor and IB4 binding sites

1999 • 835 citations

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

2000 • 798 citations

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

2000 • 766 citations

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

1992 • 597 citations

Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

2001 • 506 citations

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat

1983 • 499 citations

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

2001 • 493 citations

Parallel circuits mediating distinct emotional coping reactions to different types of stress

2001 • 491 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Pain modulation: expectation, opioid analgesia and virtual pain

2000 • 420 citations

VR1 protein expression increases in undamaged DRG neurons after partial nerve injury

2001 • 383 citations

The Midbrain Periaqueductal Gray Matter

1991 • 313 citations

Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla

1995 • 284 citations

Pharmacology and mechanisms of opioid analgesic activity

1997 • 278 citations

Endovanilloid signaling in pain

2002 • 271 citations

Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla

1994 • 267 citations

Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat

1984 • 262 citations

Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid Receptors

2003 • 256 citations

Direct and indirect actions of morphine on medullary neurons that modulate nociception

1992 • 235 citations

Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat

1982 • 210 citations

Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats

1970 • 194 citations

Subregions of the periaqueductal gray topographically innervate the rostral ventral medulla in the rat

1991 • 188 citations

VR1, but not P2X3, increases in the spared L4 DRG in rats with L5 spinal nerve ligation

2002 • 185 citations

Putative Nociceptive Modulating Neurons in the Rostral Ventromedial Medulla of the Rat: Firing of On- and Off-Cells Is Related to Nociceptive Responsiveness

1989 • 184 citations

Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells

1996 • 183 citations

Putative pain modulating neurons in the rostral ventral medulla: Reflex-related activity predicts effects of morphine

1986 • 168 citations

Existence of capsaicin-sensitive glutamatergic terminals in rat hypothalamus

1998 • 166 citations

An examination of the central sites of action of cannabinoid-induced antinociception in the rat

1995 • 162 citations

Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus In vitro

2002 • 158 citations

Morphine microinjected into the periaqueductal gray has differential effects on 3 classes of medullary neurons

1986 • 149 citations

Changes in Gene Expression and Neuronal Phenotype in Brain Stem Pain Modulatory Circuitry After Inflammation

2002 • 140 citations

Interaction between vanilloid and glutamate receptors in the central modulation of nociception

2002 • 139 citations

Vanilloid receptor VR1 is both presynaptic and postsynaptic in the superficial laminae of the rat dorsal horn

2001 • 139 citations

Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization

2001 • 136 citations

Hyperalgesia to heat after intradermal injection of capsaicin

1987 • 125 citations

Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray

1987 • 123 citations

Inflammatory Mediators at Acidic pH Activate Capsaicin Receptors in Cultured Sensory Neurons From Newborn Rats

1998 • 112 citations

Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity

2002 • 100 citations

Interactions Between Descending Pathways from the Dorsal and Ventrolateral Periaqueductal Gray Matter in the Rat

1991 • 100 citations

Is there a facilitating component to central pain modulation?

1992 • 99 citations

Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats

2002 • 99 citations

Pharmacological characterization of vanilloid receptor located in the brain

2002 • 88 citations

Periaqueductal gray matter metabotropic glutamate receptors modulate formalin-induced nociception

2000 • 87 citations

Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations

1996 • 80 citations

Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors

1999 • 67 citations

Projections from the periaqueductal gray matter to the B₃ cellular area (nucleus raphe magnus and nucleus reticularis paragigantocellularis) as revealed by the retrograde transport of horseradish peroxidase in the rat

1984 • 66 citations

The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia

1998 • 63 citations

Characterisation of mGluRs which modulate nociception in the PAG of the mouse

1998 • 54 citations

Interaction between metabotropic and NMDA glutamate receptors in the periaqueductal grey pain modulatory system

2001 • 50 citations

Reflex-related activation of putative pain facilitating neurons in rostral ventromedial medulla requires excitatory amino acid transmission

1997 • 50 citations

Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed and carrageenan inflamed rats

2002 • 41 citations

Capsaicin activated currents in rat dorsal root ganglion cells

1996 • 33 citations

Intraventricular capsaicin: Alterations in analgesic responsivity without depletion of substance P

1982 • 30 citations

Capsaicin in the 4th ventricle abolishes retching and transmission of emetic vagal afferents to solitary nucleus neurons

1997 • 29 citations

The capsaicin sensitivity of the preoptic region is preserved in adult rats pretreated as neonates, but lost in rats, pretreated as adults

1983 • 27 citations

Two distinct unit activity responses to morphine in the rostral ventromedial medulla of awake rats

1993 • 24 citations

Thermogenesis mediated by a capsaicin-sensitive area in the ventrolateral medulla

2000 • 22 citations

Pain-Modulating Neurons and Behavioral State

1998 • 18 citations

Stimulatory effect of centrally injected capsaicin, an agonist of vanilloid receptors, on gastric acid secretion in rats

2001 • 16 citations

Capsaicin treatment and stress-induced analgesia

1983 • 16 citations