Spinal effect of the cholecystokinin-B receptor antagonist CI-988 on hyperalgesia, allodynia and morphine-induced analgesia in diabetic and mononeuropathic rats

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions

1995 • 828 citations

Two brain cholecystokinin receptors: implications for behavioral actions

1986 • 719 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

1990 • 501 citations

A method to perform direct transcutaneous intrathecal injection in rats

1994 • 499 citations

Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain

1993 • 447 citations

The pathophysiology of chronic pain — increased sensitivity to low threshold Aβ-fibre inputs

1994 • 396 citations

The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat

1990 • 270 citations

The role of CCK, caerulein, and CCK antagonists in nociception

1989 • 246 citations

Statistical analysis of drug combinations for synergism

1992 • 235 citations

Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat

1987 • 179 citations

Up-regulation of cholecystokinin in primary sensory neurons is associated with morphine insensitivity in experimental neuropathic pain in the rat

1993 • 172 citations

Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics

1994 • 172 citations

Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260

1990 • 170 citations

PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

1990 • 169 citations

Cholecystokinin and morphine analgesia: variations on a theme

1994 • 165 citations

Intractable pain of spinal cord origin: clinical features and implications for surgery

1992 • 142 citations

Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil

1996 • 135 citations

Cholecystokinin in Mammalian Primary Sensory Neurons and Spinal Cord: In Situ Hybridization Studies in Rat and Monkey

1993 • 110 citations

Increased release of immunoreactive cholecystokinin octapeptide by morphine and potentiation of μ-opioid analgesia by CCKB receptor antagonist L-365,260 in rat spinal cord

1993 • 108 citations

Cholecystokinin as a factor in the enhanced potency of spinal morphine following carrageenin inflammation

1993 • 96 citations

Neurophysiology of opioid poorly responsive pain.

1994 • 83 citations

Chronic pain-related behaviors in spinally injured rats: Evidence for functional alterations of the endogenous cholecystokinin and opioid systems

1994 • 83 citations

CI988, a selective antagonist of cholecystokinin_B receptors, prevents morphine tolerance in the rat

1992 • 76 citations

Is the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics?

1998 • 74 citations

Opiate Antagonistic Function of Cholecystokinin in Analgesia and Energy Balance Systemsa

1985 • 63 citations

The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats

1994 • 60 citations

Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat

1994 • 45 citations

The CCK-B antagonist CI988 enhances the reflex-depressive effect of morphine in axotomized rats

1994 • 44 citations

A selective CCKB receptor antagonist potentiates μ-, but not δ-opioid receptor-mediated antinociception in the formalin test

1995 • 43 citations

Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins

1996 • 34 citations

Actions of Cholecystokinin Octapeptide on Rat Spinal Dorsal Horn Neuronsa

1985 • 32 citations

Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat

1995 • 32 citations

Cholecystokinin octapeptide in rat central nervous system: Immunocytochemical studies using a monoclonal antibody that does not react with CGRP

1987 • 29 citations

Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine‐induced analgesia in mononeuropathic and diabetic rats

1999 • 28 citations

The contrasting effects of dendrotoxins and other potassium channel blockers in the CA1 and dentate gyrus regions of rat hippocampal slices

1997 • 25 citations

In mononeuropathic rats, the enhancement of morphine antinociception by L-365,260, a selective CCKB receptor antagonist, depends on the dose of systemic morphine and stimulus characteristics

1997 • 24 citations