Reversal of defective peripheral nerve conduction velocity, nutritive endoneurial blood flow, and oxygenation by a novel aldose reductase inhibitor, WAY-121,509, in streptozotocin-induced diabetic rats

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

ENDONEURIAL BLOOD FLOW AND OXYGEN TENSION IN THE SCIATIC NERVES OF RATS WITH EXPERIMENTAL DIABETIC NEUROPATHY

1984 • 413 citations

Hyperglycemic pseudohypoxia and diabetic complications

1993 • 305 citations

Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits

1991 • 283 citations

Sural nerve oxygen tension in diabetes.

1986 • 258 citations

Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats

1994 • 244 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Nerve Blood Flow and Oxygen Delivery In Normal, Diabetic, and Ischemic Neuropathy

1989 • 212 citations

Determination of monosaccharides as aldononitrile, O-methyloxime, alditol, and cyclitol acetate derivatives by gas chromatography

1984 • 204 citations

Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats

1993 • 185 citations

Impaired blood flow and arterio-venous shunting in human diabetic neuropathy: a novel technique of nerve photography and fluorescein angiography

1993 • 169 citations

A DESCRIPTIVE STUDY OF THE BLOOD VESSELS OF THE SCIATIC NERVE IN THE RAT, MAN AND OTHER MAMMALS

1984 • 162 citations

Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals

1992 • 161 citations

Direct Measurement of Polyol Pathway Activity in the Ocular Lens

1984 • 153 citations

A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy

1990 • 142 citations

Angiotensin converting enzyme inhibition prevents development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin-diabetic rats

1992 • 139 citations

Aldose Reductase Inhibition: An Approach to the Prevention of Diabetic Complications

1987 • 124 citations

Effect of Prostaglandin E1 Analogue TFC 612 on Diabetic Neuropathy in Streptozocin-Induced Diabetic Rats Comparison With Aldose Reductase Inhibitor ONO 2235

1989 • 123 citations

Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy

1986 • 123 citations

Potential Therapeutic Approaches to the Treatment or Prevention of Diabetic Neuropathy: Evidence from Experimental Studies

1993 • 121 citations

PROSTACYCLIN AND NORADRENALINE IN PERIPHERAL NERVE OF CHRONIC EXPERIMENTAL DIABETES IN RATS

1989 • 116 citations

Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: Dose-response considerations and independence from a myo-inositol mechanism

1994 • 110 citations

The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

1986 • 102 citations

Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

1993 • 95 citations

The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus.

1988 • 92 citations

Pathogenesis and prevention of diabetic neuropathy

1988 • 91 citations

Pharmacological manipulation of vascular endothelium function in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization

1993 • 84 citations

Hypoxic effect of exogenous insulin on normal and diabetic peripheral nerve

1994 • 82 citations

Novel Spirosuccinimide Aldose Reductase Inhibitors Derived from Isoquinoline-1,3-diones: 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(11H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and Congeners. 1

1994 • 82 citations

THE EFFECT OF ALDOSE REDUCTASE INHIBITION ON THE PATTERN OF NERVE CONDUCTION DEFICITS IN DIABETIC RATS

1989 • 77 citations

Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat

1991 • 73 citations

Angiotensin II receptor blockade improves nerve function, modulates nerve blood flow and stimulates endoneurial angiogenesis in streptozotocin-diabetic ratsand nerve function

1993 • 70 citations

Analysis of H2 clearance curves used to measure blood flow in rat sciatic nerve.

1989 • 70 citations

Effect of Niceritrol on Streptozocin-Induced Diabetic Neuropathy in Rats

1992 • 68 citations

Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy

1993 • 68 citations

Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235

1989 • 68 citations

Effect of Aldose Reductase Inhibitor (Sorbinil) on Integration of Polyol Pathway, Pentose Phosphate Pathway, and Glycolytic Route in Diabetic Rat Lens

1986 • 67 citations

Correlations between nerve function and tissue oxygenation in diabetic patients: further clues to the aetiology of diabetic neuropathy?

1992 • 67 citations

Fine-structural localization of aldose reductase and ouabain-sensitive, K+-dependent p-nitro-phenylphosphatase in rat peripheral nerve

1991 • 65 citations

Withdrawal of the aldose reductase inhibitor tolrestat in patients with diabetic neuropathy: Effect on nerve function

1993 • 64 citations

Aldose reductase inhibitors: Recent developments

1993 • 62 citations

Direct measurement of polyol pathway activity in the ocular lens

1984 • 58 citations

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

1988 • 57 citations

Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes

1989 • 55 citations

Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve

1994 • 47 citations

Beneficial effect of the Ca²⁺ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat

1994 • 46 citations

Hyperemia of injured peripheral nerve: sensitivity to CGRP antagonism

1992 • 45 citations

Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus.

1986 • 39 citations

Prevention and reversal of motor and sensory peripheral nerve conduction abnormalities in streptozotocin-diabetic rats by the prostacyclin analogue iloprost

1993 • 38 citations

Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats

1992 • 37 citations

Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats

1992 • 36 citations

Sorbinil Partially Prevents Decreased Erythrocyte Deformability in Experimental Diabetes Mellitus

1987 • 34 citations

Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes

1991 • 30 citations

Sorbinil partially prevents decreased erythrocyte deformability in experimental diabetes mellitus

1987 • 22 citations

Adenosine Triphosphatase Activity in Sciatic Nerve Tissue of Streptozocin-Induced Diabetic Rats with and without High Dietary Sucrose: Effect of Aldose Reductase Inhibitors

1991 • 19 citations

Effect of Statil (ICI 128436) on Erythrocyte Viscosity In Vitro

1988 • 17 citations

Effect of statil (ICI 128436) on erythrocyte viscosity in vitro

1988 • 11 citations