Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats

Methods of Enzymatic Analysis

1974 • 6,512 citations

The Sorbitol Pathway and the Complications of Diabetes

1973 • 750 citations

Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus

1975 • 326 citations

Aldose Reductase Inhibition Improves Nerve Conduction Velocity in Diabetic Patients

1983 • 314 citations

Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor

1973 • 262 citations

Diabetic Neuropathy—New Concepts of Its Etiology

1979 • 218 citations

Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats

1983 • 215 citations

Red Cell Sorbitol: An Indicator of Diabetic Control

1980 • 155 citations

The Effect of Aldose Reductase Inhibition on Motor Nerve Conduction Velocity in Diabetic Rats

1982 • 154 citations

Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes

1973 • 154 citations

Peripheral nerves in early experimental diabetes

1978 • 143 citations

TREATMENT OF SEVERELY PAINFUL DIABETIC NEUROPATHY WITH AN ALDOSE REDUCTASE INHIBITOR: RELIEF OF PAIN AND IMPROVED SOMATIC AND AUTONOMIC NERVE FUNCTION

1983 • 142 citations

CP-45,634: A novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats

1979 • 137 citations

Reversal, by treatment with an aldose reductase inhibitor, of impaired axonal transport and motor nerve conduction velocity in experimental diabetes mellitus

1982 • 116 citations

Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: The effect of aldose reductase inhibition

1983 • 114 citations

Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats

1983 • 113 citations

Glucose utilization by the polyol pathway in human erythrocytes

1970 • 109 citations

Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.

1981 • 88 citations

Clinical Trial of an Aldose Reductase Inhibitor in Diabetic Neuropathy

1981 • 83 citations

Metabolic abnormalities in diabetic peripheral nerve: Relation to impaired function

1983 • 75 citations

Diabetes induced by a high fructose diet

1977 • 52 citations