Comparative Modeling of Amoebapores and Granulysin Based on the NK-Lysin Structure Structural and Functional Implications

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

WHAT IF: A molecular modeling and drug design program

1990 • 3,484 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

1998 • 1,019 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Membrane Pores Induced by Magainin

1996 • 758 citations

The crystal structure of diphtheria toxin

1992 • 663 citations

Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin

1997 • 590 citations

Magainins as paradigm for the mode of action of pore forming polypeptides

1998 • 574 citations

Structure of the membrane-pore-forming fragment of colicin A

1989 • 333 citations

NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.

1995 • 279 citations

Molecular recognition between membrane-spanning polypeptides

1995 • 277 citations

Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins.

1997 • 259 citations

Cytolytic pore-forming proteins and peptides: is there a common structural motif?

1991 • 227 citations

Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure.

1995 • 205 citations

Pore-forming peptide of pathogenic Entamoeba histolytica.

1991 • 203 citations

Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity

1997 • 165 citations

The structure and organization within the membrane of the helices composing the pore-forming domain of Bacillus thuringiensis δ-endotoxin are consistent with an “umbrella-like” structure of the pore

1998 • 163 citations

Modulation of Magainin 2−Lipid Bilayer Interactions by Peptide Charge

1997 • 156 citations

Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore bacterial cytoplasmic membranes

1994 • 149 citations

An amphipathic helical motif common to tumourolytic polypeptide NK‐lysin and pulmonary surfactant polypeptide SP‐B

1995 • 147 citations

Granulysin-Induced Apoptosis. I. Involvement of at Least Two Distinct Pathways

1998 • 133 citations

NK-lysin, a Disulfide-containing Effector Peptide of T-lymphocytes, Is Reduced and Inactivated by Human Thioredoxin Reductase

1996 • 127 citations

Amoebapores

1997 • 125 citations

Crystal Structure of Rat Bcl-xL

1997 • 121 citations

Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica

1997 • 112 citations

Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica.

1992 • 110 citations

Antimicrobial and cytolytic polypeptides of amoeboid protozoa - effector molecules of primitive phagocytes

1999 • 98 citations

Assessment of comparative modeling in CASP2

1997 • 79 citations

Assessment of comparative modeling in CASP2

1997 • 73 citations

Lipid membrane binding of NK‐lysin

1998 • 59 citations

The pore-forming peptide of Entamoeba histolytica, the protozoan parasite causing human amoebiasis

1994 • 50 citations

Pore‐forming peptide of Entamoeba histolytica significance of positively charged amino acid residues for its mode of action

1994 • 40 citations

Interaction of NK Lysin, a Peptide Produced by Cytolytic Lymphocytes, with Endotoxin

1999 • 35 citations