Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

Towards a network theory of the immune system.

1974 • 3,379 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine

1982 • 975 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.

1966 • 825 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Immunoglobulin producing hybrid cell lines

1980 • 620 citations

Properties and Applications of Monoclonal Antibodies Directed against Determinants of the Thy-1 Locus

1979 • 595 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Structure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution

1986 • 492 citations

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

1987 • 473 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.

1977 • 409 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Profiles of Antinuclear Antibodies in Systemic Rheumatic Diseases

1975 • 365 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Systemic autoimmune disease arises from polyclonal B cell activation.

1987 • 314 citations

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 • 303 citations

Idiotypic cross-reactions of monoclonal human lupus autoantibodies.

1983 • 285 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1988 • 275 citations

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney.

1989 • 265 citations

The lupus autoantigens and the pathogenesis of systemic lupus erythematosus

1986 • 259 citations

Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6.

1986 • 222 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells.

1987 • 204 citations

Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA.

1984 • 176 citations

Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA.

1981 • 171 citations

Interaction of mutant lpr gene with background strain influences renal disease

1985 • 168 citations

Presence of anti-Sm reactivity in autoimmune mouse strains

1978 • 168 citations

V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice.

1988 • 162 citations

Classification of mouse VK groups based on the partial amino acid sequence to the first invariant tryptophan: Impact of 14 new sequences from IgG myeloma proteins

1982 • 156 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

Molecular basis of a mouse strain-specific anti-hapten response

1983 • 150 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.

1982 • 143 citations

Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.

1988 • 141 citations

A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-Ipr/Ipr mice.

1982 • 139 citations

Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells.

1986 • 139 citations

Polyreactive autoantibodies are nephritogenic in murine lupus nephritis.

1987 • 139 citations

IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection.

1989 • 131 citations

The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.

1984 • 128 citations

Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus.

1983 • 127 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

Heterogeneity in Extent of the Combining Regions of Human Antidextran

1956 • 121 citations

The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

1985 • 120 citations

Enzyme immunoassay for antibodies to native DNA

1983 • 118 citations

Dermatopathological studies on skin lesions of MRL mice

1984 • 117 citations

Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice.

1988 • 110 citations

Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.

1987 • 110 citations

The NZB X SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity.

1987 • 102 citations

A MEMBER OF A NEW V_H GENE FAMILY ENCODES ANTI‐BROMELINIZED MOUSE RED BLOOD CELL AUTOANTIBODIES

1988 • 92 citations

Lymphocyte Hybridomas

1979 • 91 citations

Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice.

1988 • 85 citations

Ipr gene control of the anti-DNA antibody response.

1982 • 83 citations

A limited number of B cell lineages generates the heterogeneity of a secondary immune response.

1987 • 83 citations

The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus.

1987 • 82 citations

In vivo effects of antibodies against a high frequency idiotype of anti-DNA antibodies in MRL mice.

1984 • 82 citations

A recognition site on synthetic helical oligonucleotides for monoclonal anti-native DNA autoantibody.

1986 • 79 citations

Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity.

1984 • 77 citations

Two V kappa germ-line genes related to the GAT idiotypic network (Ab1 and Ab3/Ab1') account for the major subfamilies of the mouse V kappa-1 variability subgroup.

1987 • 76 citations

A new murine Ig VH gene family.

1988 • 75 citations

Rheumatoid factors and secondary immune responses in the mouse I. Frequent occurrence of hybridomas secreting IgM anti‐IgG₁autoantibodies after immunization with protein antigens

1983 • 74 citations

The Antibody Repertoire of Hybrid Cell Lines Obtained by Fusion of X63-AG8 Myeloma Cells with Mitogen-Activated B-Cell Blasts

1979 • 74 citations

The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice.

1987 • 72 citations

In vitro production of an anti-DNA idiotype by lymphocytes of normal subjects and patients with systemic lupus erythematosus

1986 • 70 citations

Clonal analysis of the anti-DNA repertoire of murine B lymphocytes.

1987 • 68 citations

Autoimmunization in murine graft-vs-host disease. I. Selective production of antibodies to histones and DNA.

1985 • 67 citations

Serum IgG and IgM Rheumatoid Factors by Solid Phase Radioimmunoassay

1981 • 65 citations

Eleven MRL-lpr/lpr anti-DNA autoantibodies are encoded by genes from four VH gene families: a potentially biased usage of VH genes.

1987 • 65 citations

The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system.

1985 • 63 citations

A central anti‐DNA idiotype in human and murine systemic lupus erythematosus

1985 • 59 citations

A simple enzyme-linked immunosorbent assay for antibodies to native DNA

1981 • 57 citations

Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr mice

1988 • 53 citations

Polymorphism in immunoglobulin heavy chains suggesting gene conversion.

1982 • 50 citations

Further evidence against random polyclonal antibody formation in mice with lupus-like graft-vs-host disease.

1984 • 48 citations

Autoantibody production is associated with polyclonal B cell activation in autoimmune mice which express the lpr or gld genes

1988 • 44 citations

Structural relationships among mouse and human immunogtobulin V_Hgenes in the subgroup III

1983 • 41 citations

Plasmacytomas of the NZB Mouse

1978 • 34 citations

The Ig germline gene repertoire: economy or wastage?

1988 • 20 citations

Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1s.

1989 • 20 citations

Specific inhibition of the DNA-anti-DNA immune reaction by low molecular weight anionic compounds.

1988 • 19 citations

Immunochemical studies on dextran-specific and levan-specific myeloma proteins from nzb mice

1978 • 19 citations

Influence of assay conditions on ELISA determinations of anti-DNA antibodies

1984 • 18 citations

The Organization of the Immunoglobulin Kappa Locus in Mice

1988 • 10 citations

The effect of toluidine blue and methylene blue in immunochemical reactions in vitro

1987 • 3 citations

Chimeric mouse-human IgGiantibody thatcanmediate lysis of cancer cells

1987 • 2 citations