Essential Role of NF-E2 in Remodeling of Chromatin Structure and Transcriptional Activation of the ε-Globin Gene In Vivo by 5′ Hypersensitive Site 2 of the β-Globin Locus Control Region

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

The erythroid-specific transcription factor eryf1: A new finger protein

1989 • 608 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

Functional Synergy and Physical Interactions of the Erythroid Transcription Factor GATA-1 with the Krüppel Family Proteins Sp1 and EKLF

1995 • 475 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

The Molecular Basis of Blood Diseases

1994 • 370 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

1993 • 260 citations

Nucleosome Positioning: Occurrence, Mechanisms, and Functional Consequences

1991 • 248 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

1993 • 226 citations

A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

1996 • 220 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

Self-Association of the Erythroid Transcription Factor GATA-1 Mediated by Its Zinc Finger Domains

1995 • 189 citations

Analysis of Mice Containing a Targeted Deletion of β-Globin Locus Control Region 5′ Hypersensitive Site 3

1996 • 179 citations

Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.

1993 • 169 citations

Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

1990 • 161 citations

Chromatin Structure and RNA Polymerase II Connection: Implications for Transcription

1996 • 159 citations

Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

1989 • 158 citations

Dependence of Globin Gene Expression in Mouse Erythroleukemia Cells on the NF-E2 Heterodimer

1995 • 158 citations

Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.

1996 • 156 citations

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

1990 • 151 citations

Regulation of Globin Gene Expression in Erythroid Cells

1995 • 143 citations

Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae.

1990 • 143 citations

Hypersensitive site 4 of the human β globin locus control region

1991 • 141 citations

Inducible transcription of five globin genes in K562 human leukemia cells.

1983 • 138 citations

NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.

1995 • 137 citations

GATA1 and YY1 are developmental repressors of the human epsilon-globin gene.

1995 • 128 citations

Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers.

1993 • 126 citations

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.

1991 • 121 citations

Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains.

1988 • 120 citations

Nucleosomes are phased along the mouse β-major globin gene in erythroid and nonerythroid cells

1986 • 119 citations

Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells.

1984 • 118 citations

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.

1985 • 106 citations

NF-E2 Disrupts Chromatin Structure at Human β-Globin Locus Control Region Hypersensitive Site 2 In Vitro

1996 • 104 citations

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.

1993 • 103 citations

Developmental regulation of human β-globin gene transcription: a switch of loyalties?

1993 • 100 citations

The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box.

1992 • 98 citations

Mechanism of DNase I hypersensitive site formation within the human globin locus control region.

1992 • 95 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

Multiple elements in human β-globin locus control region 5′ HS 2 are involved in enhancer activity and position independent, transgene expression

1994 • 87 citations

Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice.

1992 • 85 citations

Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure during latent infection.

1993 • 84 citations

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

1992 • 79 citations

The mouse albumin promoter and a distal upstream site are simultaneously DNase I hypersensitive in liver chromatin and bind similar liver-abundant factors in vitro.

1988 • 73 citations

Developmentally regulated and erythroid-specific expression of the human embryonic β-globin gene in transgenic mice

1990 • 68 citations

Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter.

1991 • 58 citations

Regulated expression of the beta-globin gene locus in synthetic nuclei.

1994 • 57 citations

Enhancer-Dependent Transcription of the ε-Globin Promoter Requires Promoter-Bound GATA-1 and Enhancer-Bound AP-1/NF-E2

1993 • 56 citations

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

1992 • 53 citations

Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements.

1993 • 47 citations

Dual promoter activation by the human beta-globinlocus control region.

1994 • 35 citations

The chromatin structure of the human ε globin gene: nuclease hypersensitive sites correlate with multiple Initiation sites of transcription

1984 • 30 citations

The promoter and enhancer of the inactive chicken β-globin gene contains precisely positioned nucleosomes

1991 • 15 citations

Autonomous, Erythroid-Specific DNase I Hypersensitive Site Formed by Human β-Globin Locus Control Region (LCR) 5′ HS 2 in Transgenic Mice

1995 • 12 citations

Correlation between Patterns of DNase I-Hypersensitive Sites and Upstream Promoter Activity of the Human ε-Globin Gene at Different Stages of Erythroid Development

1990 • 12 citations