pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src.

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

1985 • 386 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

pp60c-src is developmentally regulated in the neural retina

1984 • 299 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

The nucleotide sequence and the tissue-specific expression of Drosophila c-src

1985 • 201 citations

Fetal Bovine Serum: A Multivariate Standard

1975 • 182 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

1986 • 174 citations

Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

1986 • 171 citations

Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

1985 • 171 citations

The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication

1988 • 169 citations

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

1984 • 163 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.

1986 • 147 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.

1988 • 136 citations

Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts.

1983 • 118 citations

p60c-src activity detected in the chromaffin granule membrane

1986 • 109 citations

N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

1985 • 88 citations

Activation of the pp60c-src kinase during differentiation of monomyelocytic cells in vitro.

1986 • 87 citations

Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.

1984 • 81 citations

Amino Acid Alterations Within a Highly Conserved Region of the Rous Sarcoma Virus src Gene Product pp60^src Inactivate Tyrosine Protein Kinase Activity

1984 • 75 citations

Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

1989 • 75 citations

Subcellular Localization of pp60 src in RSV-Transformed Cells

1983 • 73 citations

Cancer cells 2: Oncogenes and viral genes

1985 • 51 citations

Mutations around the NG59 lesion indicate an active association of polyoma virus middle-T antigen with pp60c-src is required for cell transformation.

1986 • 42 citations

Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein

1987 • 41 citations

Oncogene-mediated multistep transformation of C3H10T1/2 cells.

1987 • 37 citations

Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein

1986 • 34 citations

pp60^c‐src is a substrate for phosphorylation when cells are stimulated to enter cycle

1984 • 30 citations

Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal growth factor

1983 • 28 citations

Transformation of NIH 3T3 cells by cotransfection with c-src and nuclear oncogenes.

1987 • 26 citations

Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.

1988 • 19 citations

Reconstitution of the Rous Sarcoma Virus Transforming Protein pp60^v-src into Phospholipid Vesicles

1988 • 12 citations

Reconstitution of the Rous sarcoma virus transforming protein pp60v-src into phospholipid vesicles.

1988 • 12 citations

Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus.

1987 • 9 citations