Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe

1998 • 2,230 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Thiamine-repressible expression vectors pREP and pRIP for fission yeast

1993 • 1,013 citations

Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression

1994 • 968 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

A cyclin associated with the CDK-activating kinase MO15

1994 • 267 citations

A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

1996 • 267 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

The cdk-activating kinase (CAK): from yeast to mammals

1999 • 239 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

The Cdk-Activating Kinase (CAK) from Budding Yeast

1996 • 220 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

1995 • 200 citations

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity

1998 • 192 citations

Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein

1988 • 189 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.

1987 • 177 citations

A Cyclin-Dependent Kinase-Activating Kinase (CAK) in Budding Yeast Unrelated to Vertebrate CAK

1996 • 174 citations

Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase

1996 • 172 citations

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.

1996 • 164 citations

Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex

1988 • 148 citations

Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae

1986 • 125 citations

A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.

1995 • 123 citations

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

1996 • 119 citations

4 Transformation of Yeast by the Lithium Acetate/Single-Stranded Carrier DNA/PEG Method

1998 • 117 citations

Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities

1998 • 108 citations

cdc2 and the regulation of mitosis: six interacting mcs genes.

1989 • 103 citations

p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

1990 • 99 citations

Molecular cloning and characterization of the Schizosaccharomyces pombe his3 gene for use as a selectable marker

1994 • 98 citations

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

1986 • 96 citations

Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo

1998 • 95 citations

Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity

1998 • 94 citations

Identification of a cdk-activating kinase in fission yeast.

1995 • 91 citations

Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.

1995 • 85 citations

Genes For Tfb2, Tfb3, and Tfb4 Subunits of Yeast Transcription/Repair Factor IIH

1997 • 79 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

Cak1 Is Required for Kin28 Phosphorylation and Activation In Vivo

1998 • 71 citations

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

1993 • 67 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe P34cdc2 function

1992 • 66 citations

Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs)

1999 • 66 citations

Fission yeast Csk1 is a CAK-activating kinase (CAKAK)

1998 • 65 citations

Regulation of CDKs by phosphorylation

1998 • 63 citations

Analysis of CAK activities from human cells

2000 • 57 citations

Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p

1999 • 50 citations

Cyclin B Proteolysis and the Cyclin-dependent Kinase Inhibitor rum1p Are Required for Pheromone-induced G₁Arrest in Fission Yeast

1998 • 46 citations

The Cak1p Protein Kinase Is Required at G1/S and G2/M in the Budding Yeast Cell Cycle

1997 • 35 citations

Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast

1997 • 35 citations

Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos

2000 • 35 citations

Dephosphorylation of Threonine 169 of Cdc28 Is Not Required for Exit from Mitosis but May Be Necessary for Start in Saccharomyces cerevisiae

1996 • 31 citations

Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling xenopus egg extracts?

1997 • 31 citations

Biological activity of the mammalian RAP genes in yeast.

1990 • 27 citations

Invariant Phosphorylation of the Saccharomyces cerevisiae Cdc28 Protein Kinase

1988 • 22 citations