Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos

Principles of CDK regulation

1995 • 3,267 citations

Dissecting the Regulatory Circuitry of a Eukaryotic Genome

1998 • 1,660 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Transforming Growth Factor‐β

1990 • 696 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

A cyclin associated with the CDK-activating kinase MO15

1994 • 267 citations

DNA-replication checkpoint control at the Drosophila midblastula transition

1997 • 258 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

The cdk-activating kinase (CAK): from yeast to mammals

1999 • 239 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster

1999 • 226 citations

The Cdk-Activating Kinase (CAK) from Budding Yeast

1996 • 220 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

1995 • 200 citations

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity

1998 • 192 citations

Requirement for TFIIH kinase activity in transcription by RNA polymerase II

1995 • 189 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition

1999 • 184 citations

Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster

1988 • 183 citations

A Cyclin-Dependent Kinase-Activating Kinase (CAK) in Budding Yeast Unrelated to Vertebrate CAK

1996 • 174 citations

Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio.

1996 • 174 citations

Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase

1996 • 172 citations

Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program.

1996 • 163 citations

Dissecting the temporal requirements for homeotic gene function

1994 • 152 citations

Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

1996 • 145 citations

Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos

1988 • 138 citations

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH.

1996 • 133 citations

A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.

1995 • 123 citations

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

1998 • 106 citations

Monoclonal antibody directed against RNA polymerase II of Drosophila melanogaster

1980 • 105 citations

Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos

1997 • 102 citations

Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

1999 • 99 citations

bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo

1993 • 97 citations

Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins

1996 • 95 citations

Identification of a cdk-activating kinase in fission yeast.

1995 • 91 citations

Mitotic repression of transcription in vitro.

1993 • 90 citations

Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis

1998 • 87 citations

Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.

1995 • 85 citations

Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.

1996 • 85 citations

p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

1994 • 84 citations

Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity

1997 • 83 citations

The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo.

1990 • 77 citations

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

1993 • 67 citations

Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs)

1999 • 66 citations

Fission yeast Csk1 is a CAK-activating kinase (CAKAK)

1998 • 65 citations

Regulation of CDKs by phosphorylation

1998 • 63 citations

Zygotic activity of the nullo locus is required to stabilize the actin-myosin network during cellularization in Drosophila

1990 • 57 citations

Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p

1999 • 50 citations

Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling xenopus egg extracts?

1997 • 31 citations

[17] Phosphorylation of mammalian RNA polymerase II

1996 • 31 citations