The ins and outs of calreticulin: from the ER lumen to the extracellular space

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Calreticulin: one protein, one gene, many functions

1999 • 726 citations

Calreticulin Is Essential for Cardiac Development

1999 • 509 citations

Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum

1989 • 417 citations

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor

1994 • 389 citations

Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion

1997 • 388 citations

Isolation of a High Affinity Calcium-binding Protein from Sarcoplasmic Reticulum

1974 • 384 citations

C1q and Systemic Lupus Erythematosus

1998 • 383 citations

Calnexin, calreticulin and the folding of glycoproteins

1997 • 377 citations

Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains.

1991 • 350 citations

Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum

2000 • 331 citations

Tyrosine phosphorylation and cadherin/catenin function

1997 • 318 citations

Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth

1998 • 314 citations

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

2000 • 285 citations

Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein.

1989 • 278 citations

Calreticulin Is a Receptor for Nuclear Export

2001 • 269 citations

Overexpression of Calreticulin Increases Intracellular Ca2+ Storage and Decreases Store-operated Ca2+ Influx

1996 • 266 citations

Oligosaccharide Binding Characteristics of the Molecular Chaperones Calnexin and Calreticulin

1998 • 260 citations

Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins

1999 • 251 citations

Calreticulin inhibits repetitive intracellular Ca2+ waves

1995 • 233 citations

In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin .alpha. subunits

1991 • 225 citations

The tobacco homolog of mammalian calreticulin is present in protein complexes in vivo.

1995 • 217 citations

Focal adhesion assembly

1997 • 212 citations

Differential Modulation of SERCA2 Isoforms by Calreticulin

1998 • 209 citations

Calreticulin and Calreticulin Fragments Are Endothelial Cell Inhibitors That Suppress Tumor Growth

1999 • 182 citations

Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

1990 • 174 citations

Thrombospondin Mediates Focal Adhesion Disassembly through Interactions with Cell Surface Calreticulin

2000 • 170 citations

Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells

1991 • 162 citations

Cell Surface Calreticulin Is a Putative Mannoside Lectin Which Triggers Mouse Melanoma Cell Spreading

1995 • 160 citations

Novel functions for calreticulin: interaction with integrins and modulation of gene expression?

1994 • 151 citations

Calreticulin modulates cell adhesiveness via regulation of vinculin expression.

1996 • 142 citations

Heart, Brain, and Body Wall Defects in Mice Lacking Calreticulin

2000 • 140 citations

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

1993 • 137 citations

Characterization of the autoantigen calreticulin.

1991 • 132 citations

Identification of calreticulin as a rubella virus RNA binding protein.

1994 • 131 citations

Calreticulin Couples Calcium Release and Calcium Influx in Integrin-mediated Calcium Signaling

2000 • 126 citations

The conformation of calreticulin is influenced by the endoplasmic reticulum lumenal environment

2000 • 123 citations

Endoplasmic Reticulum Form of Calreticulin Modulates Glucocorticoid-sensitive Gene Expression

1996 • 122 citations

Mechanisms of halothane toxicity: Novel insights

1993 • 116 citations

A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule".

1990 • 116 citations

Saturation of the Endoplasmic Reticulum Retention Machinery Reveals Anterograde Bulk Flow

1999 • 116 citations

Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development.

1994 • 113 citations

Calreticulin expression in plant cells: developmental regulation, tissue specificity and intracellular distribution

1998 • 112 citations

KDEL proteins are found on the surface of NG108-15 cells

1999 • 112 citations

Golgi Apparatus Immunolocalization of Endomannosidase Suggests Post-Endoplasmic Reticulum Glucose Trimming: Implications for Quality Control

2000 • 107 citations

Functional Relationship between Calreticulin, Calnexin, and the Endoplasmic Reticulum Luminal Domain of Calnexin

2000 • 106 citations

The Mitogenic Effects of the Bβ Chain of Fibrinogen Are Mediated through Cell Surface Calreticulin

1995 • 85 citations

Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12

2000 • 84 citations

Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.

1996 • 83 citations

Interaction between a Ca²⁺-Binding Protein Calreticulin and Perforin, a Component of the Cytotoxic T-Cell Granules

1998 • 82 citations

Calreticulin Affects Focal Contact-dependent but Not Close Contact-dependent Cell-substratum Adhesion

1999 • 81 citations

Calreticulin, an Antithrombotic Agent Which Binds to Vitamin K-dependent Coagulation Factors, Stimulates Endothelial Nitric Oxide Production, and Limits Thrombosis in Canine Coronary Arteries

1995 • 81 citations

Perforin Lytic Activity Is Controlled by Calreticulin

2000 • 73 citations

Calreticulin and calnexin in plants

1998 • 73 citations

A hookworm allergen which strongly resembles calreticulin

1999 • 72 citations

Evidence That C1q Binds Specifically to C_H2-like Immunoglobulin γ Motifs Present in the Autoantigen Calreticulin and Interferes with Complement Activation

1998 • 68 citations

Calreticulin-Integrin Bidirectional Signaling Complex

1997 • 66 citations

Systemic lupus erythematosus is associated with increased auto‐antibody titers against calreticulin and Grp94, but calreticulin is not the Ro/SS‐A antigen

1994 • 64 citations

Calreticulin in T-lymphocytes. Identification of calreticulin in T-lymphocytes and demonstration that activation of T cells correlates with increased levels of calreticulin mRNA and protein.

1992 • 60 citations

Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization

2000 • 60 citations

Antibody to a cDNA-derived calreticulin protein from Amblyomma americanum as a biomarker of tick exposure in humans.

1998 • 59 citations

COUP-TF1 Antagonizes Nkx2.5-mediated Activation of the Calreticulin Gene during Cardiac Development

2001 • 58 citations

An Interaction between Ricin and Calreticulin That May Have Implications for Toxin Trafficking

2001 • 57 citations

Isolation and characterization of Leishmania donovani calreticulin gene and its conservation of the RNA binding activity

1996 • 53 citations

Implications of Calreticulin Function in Parasite Biology

1998 • 53 citations

Review : Clinical relevance of calreticulin in systemic lupus erythematosus

1997 • 46 citations

Complete congenital heart block is associated with increased autoantibody titers against calreticulin

1996 • 45 citations

Activation of human neutrophils by a synthetic anti‐microbial peptide, KLKLLLLLKLK‐NH₂, via cell surface calreticulin

1999 • 45 citations

Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

1998 • 45 citations

Anti-gliadin Antibodies in Patients with Celiac Disease Cross-react with Enterocytes and Human Calreticulin

1997 • 44 citations

Role of calreticulin in regulating intracellular Ca2+ storage and capacitative Ca2+ entry in HeLa cells

1998 • 43 citations

AC.elegans gene encodes a protein homologous to mammalian calreticulin

1992 • 41 citations

Calreticulin is transported to the surface of NG108-15 cells where it forms surface patches and is partially degraded in an acidic compartment

1999 • 41 citations

Purification of an inositol 1,4,5-trisphosphate-binding calreticulin-containing intracellular compartment of HL-60 cells

1992 • 40 citations

Nucleotide sequence of aDrosophila melanogastergene encoding a calreticulin homologue

1992 • 39 citations

Intracellular distribution of heat-induced stress glycoproteins

1997 • 33 citations

DR4Dw4/DR53 molecules contain a peptide from the autoantigen calreticulin

1995 • 33 citations

Chaperone Properties of Calreticulin.

1998 • 28 citations

Calreticulin in T Lymphocytes

1996 • 15 citations