Minireview: The New Eukaryotic Precursor Processing Proteinases

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

1990 • 259 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

1991 • 185 citations

Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10).

1990 • 163 citations

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.

1987 • 144 citations

Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.

1989 • 121 citations

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

1991 • 118 citations

The Mechanism of Action of Nerve Growth Factor

1991 • 102 citations

Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway

1990 • 74 citations

Dominant-negative mutants of a platelet-derived growth factor gene.

1990 • 63 citations

Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.

1990 • 62 citations

Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: effects of sequence alterations on efficiency of cleavage

1990 • 60 citations

Cell-Type Specific Posttranslational Processing of Peptides by Different Pituitary Cell Lines*

1990 • 49 citations

Enzymes Required For Yeast Prohormone Processing

1988 • 25 citations

The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues

1991 • 9 citations

The Mechanism Of Action Of Nerve Growth Factor

1991 • 4 citations

Characterization of Proenkephalin‐Cleaving Proteinases in Bovine Adrenal Chromaffin Granules Using [³⁵S]Proenkephalin Copolymerized into Sodium Dodecyl Sulfate‐Polyacrylamide Gel Electrophoresis

1992 • 3 citations