The GTP-Binding Domain of Class II Transactivator Regulates Its Nuclear Export

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex

2000 • 338 citations

Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA

1997 • 209 citations

Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter

2000 • 196 citations

CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm

1999 • 191 citations

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

1999 • 179 citations

Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator

1998 • 172 citations

Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling?

1998 • 161 citations

Nucleoporins Nup98 and Nup214 Participate in Nuclear Export of Human Immunodeficiency Virus Type 1 Rev

1999 • 154 citations

Acetylation by PCAF Enhances CIITA Nuclear Accumulation and Transactivation of Major Histocompatibility Complex Class II Genes

2000 • 153 citations

Interactions between the Class II Transactivator and CREB Binding Protein Increase Transcription of Major Histocompatibility Complex Class II Genes

1999 • 150 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Two-way trafficking with Ran

1998 • 142 citations

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5

1997 • 140 citations

Regulation of MHC class I and II gene transcription: differences and similarities

1998 • 139 citations

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

1997 • 129 citations

Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein

1997 • 118 citations

A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel.

1991 • 108 citations

CIITA Leucine-Rich Repeats Control Nuclear Localization, In Vivo Recruitment to the Major Histocompatibility Complex (MHC) Class II Enhanceosome, and MHC Class II Gene Transactivation

2000 • 108 citations

Transcriptional Coactivator, CIITA, Is an Acetyltransferase that Bypasses a Promoter Requirement for TAFII250

2001 • 107 citations

GTP Binding by Class II Transactivator: Role in Nuclear Import

1999 • 100 citations

Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants

1997 • 98 citations

Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains

2001 • 93 citations

A Defect in the Nuclear Translocation of CIITA Causes a Form of Type II Bare Lymphocyte Syndrome

1999 • 86 citations

Mechanisms of Nuclear Import and Export That Control the Subcellular Localization of Class II Transactivator

2001 • 66 citations

Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

1988 • 65 citations

Role of MHC class I molecules in autoimmune disease.

1997 • 60 citations

Nucleoplasmin associates with and is phosphorylated by casein kinase ii

1995 • 55 citations

Regulation of class II MHC gene expression by interferons: insights into the mechanism of action of interferon (review).

1988 • 54 citations

Self-Association of CIITA and Its Transactivation Potential

2001 • 52 citations

HIV Tat represses transcription through Spl-Like elements in the basal promoter

1995 • 49 citations

The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element

1998 • 46 citations

Self-association of Class II Transactivator Correlates with Its Intracellular Localization and Transactivation

2001 • 42 citations

MHC structure and autoimmune T cell repertoire development

1999 • 41 citations

Leucine-rich repeats of the class II transactivator control its rate of nuclear accumulation

2002 • 28 citations

CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes

1999 • 24 citations

TAFII250-independent Transcription Can Be Conferred on a TAFII250-dependent Basal Promoter by Upstream Activators

2000 • 22 citations