BAD Induces Apoptosis in Cells Over-Expressing Bcl-2 or Bcl-xL without Loss of Mitochondrial Membrane Potential

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

1997 • 302 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Proapoptotic BH3-only Bcl-2 family members induce cytochromecrelease, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

2000 • 273 citations

Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-X_L

1997 • 271 citations

Bax, but not Bcl-x _L , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1999 • 267 citations

Bak BH3 Peptides Antagonize Bcl-xL Function and Induce Apoptosis through Cytochrome c-independent Activation of Caspases

1999 • 255 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.

2000 • 167 citations

The relationship between bcl‐2 expression and response to chemotherapy in acute leukaemia

1994 • 165 citations

Dimerization Properties of Human BAD

1997 • 151 citations

Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

1996 • 138 citations

REGULATION OF CLINICAL CHEMORESISTANCE BY bcl‐2 AND BAX ONCOPROTEINS IN B‐CELL CHRONIC LYMPHOCYTIC LEUKAEMIA

1996 • 133 citations

Release of Mitochondrial Cytochrome C in Both Apoptosis and Necrosis Induced by β-Lapachone in Human Carcinoma Cells

1999 • 128 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

Blk, a BH3-containing Mouse Protein That Interacts with Bcl-2 and Bcl-xL, Is a Potent Death Agonist

1998 • 113 citations

Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7.

1998 • 94 citations

An Adherent Cell Model to Study Different Stages of Apoptosis

1995 • 78 citations

Glutamine Reduces Heat Shock–Induced Cell Death in Rat Intestinal Epithelial Cells

1998 • 71 citations

Functional Dissection of the Pro-apoptotic Protein Bik

1997 • 62 citations

Protection From Apoptosis by Steel Factor But Not Interleukin-3 Is Reversed Through Blockade of Calcium Influx

1998 • 58 citations

An Oxidative Stress-Mediated Death Pathway in Irradiated Human Leukemia Cells Mapped Using Multilaser Flow Cytometry

1998 • 48 citations

Response to interferon therapy in patients with multiple myeloma correlates with expression of the Bcl‐2 oncoprotein

1995 • 40 citations

Radiation-induced apoptosis of Ewing's sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymerase.

1995 • 28 citations

Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels.

1994 • 21 citations

Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin.

1998 • 12 citations