The Predisposition to Type 1 Diabetes Linked to the Human Leukocyte Antigen Complex Includes at Least One Non–Class II Gene

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

1989 • 260 citations

Ancestral haplotypes: conserved population MHC haplotypes

1992 • 255 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

HLA-Encoded Genetic Predisposition in IDDM: DR4 Subtypes May Be Associated With Different Degrees of Protection

1997 • 150 citations

Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region.

1995 • 119 citations

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

1998 • 116 citations

Association of HLA-A24 With Complete β-Cell Destruction in IDDM

1993 • 110 citations

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population

1994 • 101 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

The distribution of DR4 haplotypes in sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci

1995 • 96 citations

Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.

1997 • 93 citations

Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21

1997 • 93 citations

Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection

1998 • 88 citations

Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry

1998 • 86 citations

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1995 • 84 citations

A Protective Role of the Environment in the Development of Type 1 Diabetes?

1991 • 82 citations

Association of HLA-DPB1*0301 With IDDM in Mexican-Americans

1996 • 63 citations

The susceptibility to insulin-dependent diabetes mellitus bis associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3, 4 heterozygotes

1988 • 60 citations

Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus

1990 • 54 citations

Homozygous parent affected sib pair method for detecting disease predisposing variants: Application to insulin dependent diabetes mellitus

1993 • 54 citations

Genetics of IDDM: Evidence for complex inheritance with HLA

1989 • 51 citations

An intragenic polymorphism in the human tumor necrosis factor alpha (TNFA) chain-encoding gene

1996 • 37 citations

Variation in HLA-associated risks of childhood insulin-dependent diabetes in the finnish population: I. Allele effects at A, B, and DR Loci

1995 • 31 citations

No Independent Associations of LMP2 and LMP7 Polymorphisms With Susceptibility to Develop IDDM

1997 • 29 citations

HLA Associations in Insulin-Dependent Diabetes Mellitus: No Independent Association to Particular DP Genes

1997 • 27 citations

Variation in HLA‐associated risks of childhood insulin‐dependent diabetes in the finnish population: II. Haplotype effects

1995 • 25 citations