Homozygous parent affected sib pair method for detecting disease predisposing variants: Application to insulin dependent diabetes mellitus

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

THE INTERACTION OF SELECTION AND LINKAGE. I. GENERAL CONSIDERATIONS; HETEROTIC MODELS

1964 • 1,829 citations

Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations

1987 • 630 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

Polymorphism, recombination, and linkage disequilibrium within the HLA class II region.

1992 • 416 citations

Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.

1988 • 387 citations

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.

1988 • 378 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

1990 • 332 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.

1990 • 195 citations

Reference Tables of Two-Locus Haplotype Frequencies for All MHC Marker Loci

1984 • 165 citations

Disease Susceptibility Genes ‐ their Identification by Multiple Case Family Studies

1976 • 155 citations

Insulin-Dependent Diabetes Mellitus

1984 • 117 citations

The Affected Sib Pair IBD Distribution for HLA‐Linked Disease Susceptibility Genes

1978 • 114 citations

Dose Effect of Cis- and Trans-Encoded HLA-DQαβ Heterodimers in IDDM Susceptibility

1992 • 105 citations

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility

1992 • 103 citations

HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes

1986 • 99 citations

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.

1990 • 97 citations

HLA DISEASE ASSOCIATIONS: Models for Insulin Dependent Diabetes Mellitus and the Study of Complex Human Genetic Disorders

1988 • 94 citations

HLA and insulin gene associations with IDDM

1989 • 93 citations

Investigation of the mode of inheritance of the HLA associated diseases by the method of antigen genotype frequencies among diseased individuals

1983 • 90 citations

A new method to test genetic models in HLA associated diseases: the MASC method

1988 • 83 citations

HLA haplotype study of 53 juvenile insulin‐dependent diabetic (I.D.D.) families

1982 • 79 citations

HLA Genotype studies in juvenile insulin-dependent diabetes

1980 • 74 citations

The Genetics of HLA and Disease Associations

1977 • 71 citations

Genetic analysis of IDDM: Summary of GAW5 IDDM results

1989 • 64 citations

Disease Susceptibility Genes - their Identification by Multiple Case Family Studies

1976 • 62 citations

THE AFFECTED SIB METHOD. I. STATISTICAL FEATURES OF THE AFFECTED SIB-PAIR METHOD

1985 • 54 citations

The affected sib method. IV. Sib trios

1985 • 53 citations

Genetics of IDDM: Evidence for complex inheritance with HLA

1989 • 51 citations

Trans-racial studies implicate HLA-DQ as a component of genetic susceptibility to Type 1 (insulin-dependent) diabetes

1988 • 50 citations

Three-Allele Synergistic Mixed Model for Insulin-Dependent Diabetes Mellitus

1986 • 43 citations

Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system.

1983 • 43 citations

Islet Cell Antibodies and Histocompatibility Antigens (HLA) in Insulin-Dependent Diabetics and Their First-Degree Relatives

1982 • 42 citations

Class II HLA DNA polymorphisms in Type 1 (insulin-dependent) diabetic patients of North Indian origin

1988 • 36 citations

HLA-DR4 in insulin-dependent diabetic parents and their diabetic offspring: a clue to dominant inheritance.

1986 • 35 citations

Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus

1991 • 35 citations

The immunogenetics of autoimmune diseases

1991 • 31 citations

1 Overview: the major histocompatibility complex and insulin dependent diabetes mellitus

1991 • 28 citations

Non-HLA region genes in insulin dependent diabetes mellitus

1991 • 25 citations

7 Trans-racial gene mapping studies

1991 • 25 citations

Heterogeneity of insulin‐dependent diabetes–new evidence

1982 • 24 citations

Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus

1991 • 16 citations

HLA class II sequences and genetic susceptibility to insulin dependent diabetes mellitus

1991 • 15 citations

Genetic analysis workshop IV: Insulin dependent diabetes mellitus - summary

1986 • 14 citations

A combined segregation and linkage analysis of insulin-dependent diabetes mellitus

1986 • 12 citations

HLA and IDDM predisposition: New aspects

1986 • 12 citations