Survivin and B7-H1 Are Collaborative Predictors of Survival and Represent Potential Therapeutic Targets for Patients with Renal Cell Carcinoma

Cancer Statistics, 2005

2005 • 5,487 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Renal-Cell Carcinoma

1996 • 2,232 citations

Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer

2001 • 1,690 citations

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy.

1995 • 1,320 citations

An Outcome Prediction Model for Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy Based on Tumor Stage, Size, Grade and Necrosis: The Ssign Score

2002 • 1,073 citations

Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation

2000 • 1,029 citations

Pathways of apoptotic and non-apoptotic death in tumour cells

2004 • 1,026 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Classification of renal cell carcinoma

1997 • 887 citations

Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up

2006 • 826 citations

Randomized Phase III Trial of High-Dose Interleukin-2 Versus Subcutaneous Interleukin-2 and Interferon in Patients With Metastatic Renal Cell Carcinoma

2004 • 801 citations

Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer

2003 • 778 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

2004 • 742 citations

Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma

2003 • 736 citations

Improved Prognostication of Renal Cell Carcinoma Using an Integrated Staging System

2001 • 712 citations

A POSTOPERATIVE PROGNOSTIC NOMOGRAM FOR RENAL CELL CARCINOMA

2001 • 706 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.

2001 • 625 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

2000 • 534 citations

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation.

1998 • 512 citations

Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting

1998 • 413 citations

Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis

2003 • 370 citations

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

2001 • 329 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 290 citations

Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients.

2001 • 258 citations

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients.

2001 • 258 citations

Role of survivin and its splice variants in tumorigenesis

2004 • 226 citations

Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference.

2003 • 191 citations

Effects of Survivin Antagonists on Growth of Established Tumors and B7-1 Immunogene Therapy

2001 • 174 citations

Treatment of Metastatic Renal Cell Carcinoma With Nephrectomy, Interleukin-2 and Cytokine-Primed or CD8(+) Selected Tumor Infiltrating Lymphocytes from Primary Tumor

1997 • 162 citations

Clear Cell Renal Cell Carcinoma: Gene Expression Analyses Identify a Potential Signature for Tumor Aggressiveness

2005 • 155 citations

The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer

2003 • 153 citations

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma.

1999 • 145 citations

Lack of toxicity of therapy-induced T cell responses against the universal tumour antigen survivin

2004 • 113 citations

High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma

2006 • 93 citations

Effect of Renal Cell Carcinomas on the Development of Type 1 T-Cell Responses

2004 • 75 citations

Mononuclear cell infiltration in clear‐cell renal cell carcinoma independently predicts patient survival

2006 • 73 citations

Downregulation of survivin expression by induction of the effector cell protease receptor-1 reduces tumor growth potential and results in an increased sensitivity to anticancer agents in human colon cancer

2002 • 64 citations

710: High Expression Levels of Survivin Protein are an Independent Predictor of Poor Outcome Among Patients Treated Surgically for Clear Cell Renal Cell Carcinoma

2006 • 4 citations