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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4

Data up to Jan 2025

Published2003
Citations141
References36

Total Citations Per Year

Abstract

References (36)

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

Rosette-Forming Human Lymphoid Cell Lines. I. Establishment and Evidence for Origin of Thymus-Derived Lymphocytes<xref ref-type="fn" rid="FN1">2</xref>

1972 • 916 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Vascular endothelial growth factor and the regulation of angiogenesis.

2000 • 528 citations

Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia

2000 • 479 citations

Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma

1995 • 469 citations

Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.

2001 • 440 citations

VEGF: an update on biological and therapeutic aspects

2000 • 372 citations

Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma

2001 • 344 citations

Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes

2001 • 336 citations

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

2001 • 275 citations

Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells

2001 • 207 citations

Expression of vascular endothelial growth factor receptors in human prostate cancer

1999 • 202 citations

De novo expression of vascular endothelial growth factor in human pancreatic cancer: Evidence for an autocrine mitogenic loop

2000 • 184 citations

Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates

1996 • 141 citations

Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid

2001 • 139 citations

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

1997 • 139 citations

Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.

1996 • 123 citations

Increased bone marrow vascularization in patients with acute myeloid leukaemia: a possible role for vascular endothelial growth factor

2001 • 117 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Inhibits Anchorage-Disruption-Induced Apoptosis in Microvessel Endothelial Cells by Inducing Scaffold Formation

1997 • 98 citations

In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells

1998 • 84 citations

Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas

2000 • 77 citations

Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production.

2000 • 70 citations

Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays

1999 • 69 citations

Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours

1999 • 65 citations

P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line.

2001 • 57 citations

Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine

2002 • 57 citations

p73 competes with p53 and attenuates its response in a human ovarian cancer cell line

2000 • 52 citations

Angiogenesis is increased in B-cell chronic lymphocytic leukemia

2001 • 29 citations

Effect of dehydrodidemnin B on human colon carcinoma cell lines.

1997 • 28 citations

Deleted Work

1955 • 0 citations

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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth… (2003) – Leukemia | Metascience Observatory Explorer