Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Proposals for the classification of the myelodysplastic syndromes

1982 • 3,616 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

1998 • 2,263 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

Macrophages and angiogenesis

1994 • 1,123 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells.

1998 • 524 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

1999 • 491 citations

Vascular Endothelial Growth Factor, a Possible Paracrine Growth Factor in Human Acute Myeloid Leukemia

1997 • 465 citations

Evidence of increased angiogenesis in patients with acute myeloid leukemia

2000 • 465 citations

Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes [see comments]

1995 • 445 citations

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

1998 • 440 citations

The Molecular Basis of Cancer

1985 • 389 citations

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.

1995 • 311 citations

Cellular Vascular Endothelial Growth Factor Is a Predictor of Outcome in Patients With Acute Myeloid Leukemia

1999 • 304 citations

Angiogenesis in myelodysplastic syndromes

1999 • 278 citations

Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes

1997 • 262 citations

A role for tumour necrosis factor‐α, Fas and Fas‐Ligand in marrow failure associated with myelodysplastic syndrome

1998 • 243 citations

Prognostic factors in the myelodysplastic syndromes: importance of initial data on peripheral blood counts, bone marrow cytology, trephine biopsy and chromosomal analysis

1985 • 217 citations

Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165

1997 • 193 citations

The Molecular Basis of Cancer

1996 • 157 citations

Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines.

1996 • 148 citations

Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor.

1995 • 116 citations

Oxidative DNA damage in CD34⁺ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor‐α concentration

1997 • 114 citations

Erythropoietin-Induced Activation of STAT5 Is Impaired in the Myelodysplastic Syndrome

1997 • 98 citations

Methodology of long-term culture of human hemopoietic cells

1991 • 91 citations

Neuropilin-1 Is Expressed on Bone Marrow Stromal Cells: A Novel Interaction With Hematopoietic Cells?

1999 • 73 citations

Impaired response of myelodysplastic marrow progenitors to stimulation with recombinant haemopoietic growth factors.

1991 • 64 citations

Multivariate analysis of prognostic factors in acute myeloid leukemia: value of clonogenic leukemic cell properties.

1989 • 47 citations

Rapid Automated CombinedIn SituHybridization and Immunohistochemistry for Sensitive Detection of Cytomegalovirus in Paraffin-Embedded Tissue Biopsies

1996 • 32 citations

Mast cell growth factor (c-kit ligand) restores growth of multipotent progenitors in myelodysplastic syndrome.

1994 • 19 citations

Combined in situ hybridization and immunohistochemistry for automated detection of cytomegalovirus and p53

1996 • 8 citations

Pharmacological differentiation and anti-apoptotic therapy in myelodysplastic syndromes.

1999 • 6 citations