Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

1999 • 748 citations

Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes

2000 • 662 citations

Bone marrow angiogenesis and progression in multiple myeloma

1994 • 656 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.

1997 • 546 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

How Tumors Become Angiogenic

1996 • 514 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Vascular Endothelial Growth Factor, a Possible Paracrine Growth Factor in Human Acute Myeloid Leukemia

1997 • 465 citations

Evidence of increased angiogenesis in patients with acute myeloid leukemia

2000 • 465 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia

1984 • 441 citations

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

2000 • 435 citations

The Molecular Basis of Cancer

1985 • 389 citations

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

1997 • 373 citations

Acute leukemia with promyelocytic features in PML/RARα transgenic mice

1997 • 366 citations

Angiogenesis in wound healing

1991 • 352 citations

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

1996 • 349 citations

Incidence, Clinical Features, and Outcome of AllTrans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia

1998 • 334 citations

Reassessing the hemostatic disorder associated with acute promyelocytic leukemia [see comments]

1992 • 306 citations

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

1991 • 291 citations

Discovery of a New Mechanism and Development of Angiogenic Therapy That Accelerates Healing

1991 • 282 citations

Platelet-Derived Growth Factor is AngiogenicIn Vivo

1992 • 276 citations

Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.

2000 • 263 citations

Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents

1994 • 241 citations

Vascular Endothelial Cell Growth Factor–Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1

1999 • 215 citations

Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia

2000 • 214 citations

Secretion of interleukin-1 by acute myeloblastic leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors

1987 • 210 citations

Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44

1995 • 139 citations

Acute promyelocytic leukemia: biology and treatment.

1997 • 138 citations

The Molecular Basis of Cancer

1996 • 131 citations

Molecular genetics of acute promyelocytic leukemia

1999 • 116 citations

Regulation of Vascular Endothelial Growth Factor Expression in Human Keratinocytes by Retinoids

2000 • 115 citations

The combination of antiagniogenic agents to inhibit primary tumor growth and metastasis

1993 • 111 citations

Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis

1998 • 98 citations

Leukemia cell lines: In vitro models for the study of acute promyelocytic leukemia

1995 • 95 citations

Current Status Of Antiangiogenic Factors

2000 • 94 citations

Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma.

1998 • 94 citations

Inhibition of squamous cell carcinoma angiogenesis by direct interaction of retinoic acid with endothelial cells.

1996 • 88 citations

Endothelial cell migratory signal produced by human endometrium during the menstrual cycle

1992 • 86 citations

Chorioallantoic placenta formation in the rat: II. Angiogenesis and maternal blood circulation in the mesometrial region of the implantation chamber prior to placenta formation

1991 • 86 citations

Angiogenesis in the Uterus: Potential Regulation and Relation to Tumor Angiogenesis

1992 • 84 citations

Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic.

1996 • 74 citations

Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia

1993 • 67 citations

Retinoids Downregulate Vascular Endothelial Growth Factor/Vascular Permeability Factor Production by Normal Human Keratinocytes

1998 • 60 citations

Differentiating therapy in acute myeloid leukemia.

1996 • 53 citations

Bone marrow stromal cell changes in haematological malignancies.

1990 • 39 citations

Establishment of a human acute promyelocytic leukemia-ascites model in SCID mice

1996 • 32 citations

Role of colony‐stimulating factors in the biology of acute myelogenous leukemia

1989 • 29 citations