Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Greenfield's Neuropathology

1985 • 1,149 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Selective Sparing of a Class of Striatal Neurons in Huntington's Disease

1985 • 767 citations

Cooperative Modulation of [³H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines

1988 • 755 citations

An Outbreak of Toxic Encephalopathy Caused by Eating Mussels Contaminated with Domoic Acid

1990 • 726 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels

1990 • 555 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

1986 • 545 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease

1990 • 431 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

NMDA Receptor Losses in Putamen from Patients with Huntington's Disease

1988 • 401 citations

Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.

1985 • 374 citations

LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA

1986 • 373 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Excitatory amino acids and neuropsychiatrie disorders

1989 • 327 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[³H]Glutamate Binding

1987 • 281 citations

Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts

1990 • 274 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

1989 • 245 citations

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

1988 • 222 citations

Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone

1987 • 221 citations

Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells

1988 • 212 citations

Taking apart NMDA receptors

1987 • 209 citations

Neurotoxicity ofβ-N-methylamino-l-alanine (BMAA) andβ-N-oxalylamino-l-alamine (BOAA) on cultured cortical neurons

1989 • 206 citations

Behavioral effects of MK-801 in the rat

1990 • 164 citations

Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity

1990 • 150 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

Effects of high-frequency synaptic stimulation on glumate receptor binding studied with a modified in vitro hippocampal slice preparation

1982 • 115 citations

Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning

1990 • 101 citations

Loss of hippocampal [3H]TCP binding in Alzheimer's disease

1987 • 97 citations

Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 96 citations

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

1989 • 90 citations

Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 85 citations

Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor

1990 • 83 citations

Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins

1990 • 80 citations

Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.

1990 • 78 citations

Regional changes in [3H]d-aspartate and [3H]TCP binding sites in Alzheimer's disease brains

1988 • 76 citations

Loss of glycine-dependent radioligand binding to the receptor complex in patients with Alzheimer's disease

1989 • 63 citations

1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor

1989 • 61 citations

Glutamate Neurotoxicity, Calcium, and Zinc^a

1989 • 51 citations

Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease

1986 • 49 citations

The N-methyl-d-aspartate receptor complex in Alzheimer's disease: reduced regulation by glycine but not zinc

1989 • 44 citations

[3H]MK-801 binding in Alzheimer's disease

1988 • 44 citations

Characterisation, Density, and Distribution of Kainate Receptors in Normal and Alzheimer's Diseased Human Brain

1989 • 37 citations

Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA

1989 • 30 citations

Guanine nucleotide modulation of [3H]TCP binding to the NMDA receptor complex

1990 • 24 citations

CSF zinc in Alzheimer's type dementia

1988 • 22 citations

Untitled

1984 • 21 citations

Efficacy and safety of CV-2619(idebenone)in multiple cerebral infarction, cerebrovascular dementia and senile dementia.

1985 • 9 citations

Pyramidal neuron loss and “glycine-site therapy”: A need for an animal model and study in late-life depression

1989 • 8 citations

Effects of MK-801, a non-competitive NMDA antagonist, on linguopharyngeal events in rats

1991 • 4 citations