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1996 • 5,667 citations

de la Chapelle, A.

1997 • 3,184 citations

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1999 • 2,379 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

1998 • 1,173 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1997 • 756 citations

Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.

1997 • 751 citations

Cancer risk associated with germline DNA mismatch repair gene mutations

1997 • 693 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

1998 • 523 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

1999 • 369 citations

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

1999 • 369 citations

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

1999 • 316 citations

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.

1998 • 270 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Causes and consequences of microsatellite instability in endometrial carcinoma.

1999 • 217 citations

Microsatellite Instability in Sporadic Endometrial Carcinoma

1994 • 191 citations

Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.

1996 • 185 citations

Microsatellite instability analysis: a multicenter study for reliability and quality control.

1997 • 166 citations

Prognostic Significance of Angiogenesis and Ki-67, p53, and p21 Expression: A Population-Based Endometrial Carcinoma Study

1999 • 166 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas

1996 • 149 citations

Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas.

2000 • 138 citations

Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer.

1996 • 134 citations

Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis.

2000 • 119 citations

Mutational analysis ofMLH1 andMSH2 in 25 prospectively-acquired RER+ endometrial cancers

1997 • 106 citations

Flow cytometric deoxyribonucleic acid index: A prognostic factor in endometrial carcinoma

1986 • 97 citations

Identification of high-risk patients by assessment of nuclear Ki-67 expression in a prospective study of endometrial carcinomas.

1998 • 76 citations

Microsatellite Instability and Expression of MLH1 and MSH2 in Normal and Malignant Endometrial and Ovarian Epithelium in Hereditary Nonpolyposis Colorectal Cancer Family Members

1999 • 67 citations

Prognostic Value of p53 and Proliferating Cell Nuclear Antigen Expression in Endometrial Carcinoma

1996 • 61 citations

Independent prognostic importance of microvessel density in endometrial carcinoma

1998 • 58 citations

Deletion mapping on chromosome 10q25-q26 in human endometrial cancer

1996 • 52 citations

Differences in patterns ofTP53 andKRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability

1999 • 48 citations

Poorer survival of nulliparous women with endometrial carcinoma

1998 • 43 citations

Endometrial carcinoma: the prognostic impact of papillary serous carcinoma (UPSC) in relation to nuclear grade, DNA ploidy and p53 expression.

1996 • 39 citations