Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

1985 • 402 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Microsatellite instability occurs frequently in human gastric carcinoma.

1994 • 203 citations

Microsatellite Instability in Sporadic Endometrial Carcinoma

1994 • 191 citations

Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers.

1994 • 146 citations

Expression of p53 and 17p allelic loss in colorectal carcinoma.

1992 • 130 citations

p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.

1992 • 109 citations

Mutations of the Ki-ras oncogene in carcinoma of the endometrium.

1995 • 82 citations

p53 gene mutations in human endometrial carcinoma

1992 • 80 citations

Genomic instability in neoplasia

1995 • 70 citations

Hepatitis B and Alterations of the p53 Tumor Suppressor Gene in Hepatocellular Carcinoma

1993 • 40 citations

DNA alterations in cells from hereditary non-polyposis colorectal cancer patients.

1994 • 35 citations

Loss of heterozygosity and overexpression of the p53 gene in ovarian carcinoma.

1994 • 18 citations

Quantitation of c-myc gene amplification by a competitive PCR assay system.

1993 • 16 citations