Mutational analysis ofMLH1 andMSH2 in 25 prospectively-acquired RER+ endometrial cancers

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

1991 • 2,314 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Cancer statistics, 1996

1996 • 1,807 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

1995 • 497 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Genetic instability occurs in the majority of young patients with colorectal cancer

1995 • 378 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis

1996 • 230 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

1995 • 219 citations

Inherited breast and ovarian cancer

1995 • 212 citations

DNA mismatch repair and cancer

1995 • 178 citations

p53 mutation is a common genetic event in ovarian carcinoma.

1993 • 177 citations

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

1995 • 171 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

Strand-separating conformational polymorphism analysis: Efficacy of detection of point mutations in the human ornithine δ-aminotransferase gene

1992 • 118 citations

Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and/or of poorly differentiated type

1995 • 103 citations

Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections

1995 • 96 citations

Frequent p53 gene mutations and novel alleles in familial breast cancer.

1994 • 83 citations

New phenotypic aspects in a family with lynch syndrome II

1987 • 75 citations

Relationship between race and interval to treatment in endometrial cancer

1995 • 60 citations

Genomic Organization and Expression of the Human MSH3 Gene

1996 • 54 citations

Mutations inMLH1 are more frequent than inMSH2 in sporadic colorectal cancers with microsatellite instability

1997 • 54 citations

Relationship Between Race and Interval to Treatment in Endometrial Cancer

1995 • 25 citations