Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

2017 • 8,063 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

Roles of PPARs in health and disease

2000 • 1,941 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 805 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

Diabetes mellitus : a fundamental and clinical text

2004 • 691 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1996 • 654 citations

Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists

2000 • 535 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

1998 • 395 citations

Animal and Human Calorimetry

1988 • 387 citations

Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM

1997 • 372 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

1999 • 309 citations

Efficacy and Safety of Troglitazone in the Treatment of Lipodystrophy Syndromes

2000 • 301 citations

Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

1998 • 293 citations

The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers

1998 • 259 citations

[[.omega.-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents

1994 • 259 citations

Insights into insulin resistance and type 2 diabetes from knockout mouse models

2000 • 252 citations

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.

2000 • 227 citations

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

1994 • 217 citations

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

1999 • 206 citations

Fenofibrate and Rosiglitazone Lower Serum Triglycerides with Opposing Effects on Body Weight

2000 • 198 citations

PPARγ Activation Induces the Expression of the Adipocyte Fatty Acid Binding Protein Gene in Human Monocytes

1999 • 180 citations

Impaired Glucose Tolerance is Normalized by Treatment With the Thiazolidinedione Troglitazone

1997 • 143 citations

A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

2000 • 134 citations

Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice

1999 • 120 citations

Identification of a DNA clone to phosphoenolpyruvate carboxykinase (GTP) from rat cytosol. Alterations in phosphoenolpyruvate carboxykinase RNA levels detectable by hybridization.

1981 • 100 citations

Leptin and diabetes in lipoatrophic mice

2000 • 89 citations

Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus.

1998 • 85 citations

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

2000 • 58 citations

Peroxisome Proliferator-Activated Receptor γ1 Expression Is Induced during Cyclic Adenosine Monophosphate-Stimulated Differentiation of Alveolar Type II Pneumonocytes*

1997 • 55 citations

Specificity of gene expression in adipocytes.

1985 • 36 citations

Specificity of Gene Expression in Adipocytes

1985 • 8 citations

Deleted Work

1955 • 0 citations