Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice

The MAPK signaling cascade

1995 • 3,300 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The insulin signaling system.

1994 • 1,733 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Diabetes, a New Mutation in the Mouse

1966 • 966 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1999 • 483 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

1998 • 369 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes

1999 • 316 citations

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

1998 • 293 citations

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

1996 • 278 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes*

1997 • 252 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

1997 • 138 citations

Akt-2 Binds to Glut4-containing Vesicles and Phosphorylates Their Component Proteins in Response to Insulin

1999 • 128 citations

Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

1999 • 113 citations

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

1999 • 104 citations

Cross‐talk mechanisms in the development of insulin resistance of skeletal muscle cells

1999 • 97 citations

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

1999 • 89 citations

Development of hyperglycaemia and insulin resistance in conscious genetically diabetic (C57BL/KsJ-db/db) mice

1994 • 87 citations

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

1999 • 79 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 77 citations

Regulation of Protein Kinase B in Rat Adipocytes by Insulin, Vanadate, and Peroxovanadate

1997 • 75 citations

Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus

1999 • 73 citations

Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo.

1992 • 68 citations

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

1998 • 63 citations

Effects of overexpression of human GLUT4 gene on maternal diabetes and fetal growth in spontaneous gestational diabetic C57BLKS/J Lepr(db/+) mice.

1999 • 56 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes

1997 • 55 citations

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice

1996 • 50 citations

Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia*

2000 • 44 citations

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats

1997 • 34 citations

Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex

1993 • 32 citations

Insulin-Induced Translocation of Protein Kinase B to the Plasma Membrane in Rat Adipocytes

1998 • 31 citations

Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia

2000 • 16 citations

Development of hyperglycaemia and insulin resistance in conscious genetically diabetic (C57BL/KsJ-db/db) mice

1994 • 6 citations