Statins and cancer prevention

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

1996 • 7,450 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

2002 • 6,780 citations

Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels

1998 • 5,293 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

1995 • 3,524 citations

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

2002 • 3,347 citations

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

2005 • 2,039 citations

PLEIOTROPIC EFFECTS OF STATINS

2004 • 1,860 citations

West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials

1996 • 1,584 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels

1998 • 1,398 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

2002 • 1,074 citations

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

2001 • 1,035 citations

Statins and the Risk of Colorectal Cancer

2005 • 789 citations

Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality

1997 • 737 citations

Statins Have Biphasic Effects on Angiogenesis

2002 • 659 citations

The statins as anticancer agents.

2003 • 595 citations

Relation Between Baseline and On-Treatment Lipid Parameters and First Acute Major Coronary Events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)

2000 • 571 citations

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

2002 • 557 citations

C-Reactive Protein and the Risk of Incident Colorectal Cancer

2004 • 543 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

The Risk of Cancer in Users of Statins

2004 • 514 citations

Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality

1998 • 509 citations

Sterols and Isoprenoids: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway

1999 • 463 citations

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

2002 • 361 citations

Lovastatin-mediated G ₁ arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

1999 • 344 citations

Studies of the Isoprenoid-Mediated Inhibition of Mevalonate Synthesis Applied to Cancer Chemotherapy and Chemoprevention

2004 • 335 citations

Statins as anti-inflammatory agents

2002 • 335 citations

Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)

2004 • 324 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors and the Risk of Cancer

2000 • 320 citations

Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study

2001 • 311 citations

Double-Edged Role of Statins in Angiogenesis Signaling

2002 • 307 citations

Cell cycle-specific effects of lovastatin.

1991 • 301 citations

Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

2004 • 299 citations

Isoprenoids Suppress the Growth of Murine B16 Melanomas In Vitro and In Vivo

1997 • 294 citations

Identification of FBL2 As a Geranylgeranylated Cellular Protein Required for Hepatitis C Virus RNA Replication

2005 • 293 citations

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial

2003 • 286 citations

Cancer risk among statin users: A population‐based cohort study

2004 • 267 citations

Anti-RhoA and Anti-RhoC siRNAs Inhibit the Proliferation and Invasiveness of MDA-MB-231 Breast Cancer Cells in Vitro and in Vivo

2004 • 263 citations

Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

2005 • 251 citations

Statin use and cancer risk in the General Practice Research Database

2004 • 245 citations

Safety and Tolerability of Pravastatin in Long-Term Clinical Trials

2002 • 241 citations

Statins Exert Endothelial Atheroprotective Effects via the KLF2 Transcription Factor

2005 • 239 citations

Hyaluronan-mediated CD44 Interaction with RhoGEF and Rho Kinase Promotes Grb2-associated Binder-1 Phosphorylation and Phosphatidylinositol 3-Kinase Signaling Leading to Cytokine (Macrophage-Colony Stimulating Factor) Production and Breast Tumor Progression

2003 • 235 citations

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, Rho‐, and Rac‐dependent signaling pathways

2000 • 234 citations

Statins and Prostate Cancer Risk: A Case-Control Study

2005 • 231 citations

Blocking the Raf/MEK/ERK Pathway Sensitizes Acute Myelogenous Leukemia Cells to Lovastatin-Induced Apoptosis

2004 • 222 citations

Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP.

1998 • 214 citations

Do statins cause cancer? A meta-analysis of large randomized clinical trials

2001 • 194 citations

Potential antitumor effects of statins (Review)

2003 • 191 citations

Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac

1999 • 187 citations

Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.

2001 • 183 citations

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells

2005 • 177 citations

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

2004 • 172 citations

Role of Rho-family proteins in cell adhesion and cancer

2003 • 171 citations

Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

2003 • 170 citations

Effect of Efavirenz on the Pharmacokinetics of Simvastatin, Atorvastatin, and Pravastatin

2005 • 164 citations

Might treatment of hypercholesterolaemia increase non-cardiac mortality?

1991 • 161 citations

Prior Medical Conditions and Medication use and Risk of non-Hodgkin lymphoma in Connecticut United States Women

2004 • 154 citations

Effect of statins combined with estradiol on the proliferation of human receptor-positive and receptor-negative breast cancer cells

2003 • 152 citations

Lipid-Lowering Drug Use and Breast Cancer in Older Women: A Prospective Study

2003 • 147 citations

Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis

1998 • 147 citations

Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.

2003 • 146 citations

Functional Analysis of the Contribution of RhoA and RhoC GTPases to Invasive Breast Carcinoma

2004 • 146 citations

Statin Use and the Risk of Breast and Prostate Cancer

2002 • 139 citations

Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models

2002 • 129 citations

Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis

2004 • 128 citations

Statins differ in their ability to block NF-kB activation in human blood monocytes

2003 • 128 citations

Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

2003 • 120 citations

Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism

2004 • 117 citations

The association between 3‐hydroxy‐3‐methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women

2004 • 115 citations

Lovastatin-induced apoptosis in human melanoma cell lines

2005 • 114 citations

Statins: the new aspirin?

2002 • 109 citations

Cancer prevention science and practice.

2002 • 106 citations

Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation

1998 • 101 citations

Targeting the Mevalonate Pathway Inhibits the Function of the Epidermal Growth Factor Receptor

2005 • 101 citations

Statins Can Inhibit Proliferation of Human Breast Cancer Cells in Vitro

2003 • 100 citations

Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation

2003 • 100 citations

Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis

2002 • 97 citations

Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models

2003 • 96 citations

Statin use and the risk of breast cancer

2003 • 92 citations

Statins and Cancer Development

2005 • 90 citations

Statin use, hyperlipidaemia, and the risk of breast cancer

2002 • 88 citations

Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells

2002 • 88 citations

Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis

1985 • 87 citations

Statin therapy and angiogenesis

2003 • 86 citations

p21-dependent Inhibition of Colon Cancer Cell Growth by Mevastatin Is Independent of Inhibition of G1 Cyclin-dependent Kinases

2003 • 84 citations

Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis

2004 • 83 citations

HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells

2002 • 82 citations

Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas

2004 • 82 citations

Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death

2001 • 80 citations

RETRACTED: Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study

2005 • 79 citations

Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro.

1999 • 78 citations

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

2003 • 78 citations

Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells

2001 • 76 citations

Geranylgeraniol Overcomes the Block of Cell Proliferation by Lovastatin in C6 Glioma Cells

1998 • 73 citations

The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases

2001 • 72 citations

Improved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives

2004 • 68 citations

Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells.

2002 • 67 citations

Chemoprevention by Pravastatin, a 3‐Hydroxy‐3‐methylglutaryl‐coenzyme A Reductase Inhibitor, of N‐Methyl‐N‐nitrosourea‐induced Colon Carcinogenesis in F344 Rats

1996 • 64 citations

Pro-apoptotic effect of fluvastatin on human smooth muscle cells

1999 • 64 citations

Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: A novel approach in developing effective chemopreventive regimens

2002 • 59 citations

Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells

2004 • 57 citations

Effects of Monoterpenes and Mevinolin on Murine Colon Tumor CT-26 in Vitro and its Hepatic “Metastases” in Vitro

1996 • 55 citations

Isoprenylation of Intracellular Proteins as a New Target for the Therapy of Human Neoplasms: Preclinical and Clinical Implications

2005 • 54 citations

Effects of perillyl alcohol on melanoma in the TPras mouse model.

2002 • 50 citations

Inverted signaling hierarchy between RAS and RAC in T-lymphocytes

2004 • 43 citations

Melanoma Chemoprevention: A Role for Statins or Fibrates?

2003 • 40 citations

Lovastatin and simvastatin are modulators of the proteasome

2000 • 39 citations

The Isoprenoid Substrate Specificity of Isoprenylcysteine Carboxylmethyltransferase

2005 • 38 citations

Isoprenylation is Necessary for the Full Invasive Potential of RhoA Overexpression in Human Melanoma Cells

2002 • 36 citations

Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects

2002 • 31 citations

Osteoblast-derived Oxysterol Is a Migration-inducing Factor for Human Breast Cancer Cells

2003 • 30 citations

Geranylgeranyl transferase inhibition stimulates antimelanoma immune response through MHC class I and costimulatory molecule expression

2005 • 29 citations

The effects of lovastatin on proteasome activities in highly purified rabbit 20 S proteasome preparations and mouse MC3T3-E1 osteoblastic cells

2002 • 25 citations

Reported Use of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Was Not Associated with Reduced Recurrence of Colorectal Adenomas

2005 • 23 citations

Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines

2002 • 20 citations

Breast cancer inhibition by statins

2004 • 13 citations

Statins reduce the incidence of lung cancer: A study of half a million U.S. veterans

2005 • 10 citations

Deleted Work

1955 • 0 citations