Targeting the Mevalonate Pathway Inhibits the Function of the Epidermal Growth Factor Receptor

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Cancer statistics, 2000

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PI3K/Akt signalling pathway and cancer

2003 • 2,157 citations

EGFR and cancer prognosis

2001 • 2,068 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

2002 • 910 citations

Bronchioloalveolar Pathologic Subtype and Smoking History Predict Sensitivity to Gefitinib in Advanced Non–Small-Cell Lung Cancer

2004 • 749 citations

Phase II Trial of Gefitinib in Recurrent Glioblastoma

2003 • 730 citations

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

2000 • 667 citations

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

2002 • 557 citations

Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design

1994 • 521 citations

Morphological and biochemical characterization and analysis of apoptosis

1997 • 478 citations

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

2001 • 463 citations

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

1996 • 368 citations

Twenty-Two Years of Phase III Trials for Patients With Advanced Non–Small-Cell Lung Cancer: Sobering Results

2001 • 359 citations

Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial

2001 • 354 citations

Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways.

2003 • 326 citations

Pharmacology of competitive inhibitors of HMg-CoA reductase

1995 • 276 citations

Regulation and targets of receptor tyrosine kinases

2002 • 260 citations

Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae

2002 • 213 citations

HMG CoA reductase inhibitors

1992 • 195 citations

Tyrosine kinase inhibitors—ZD1839 (Iressa)

2001 • 171 citations

Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.

2001 • 164 citations

Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell Surface

1996 • 137 citations

HMG–CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P–glycoprotein–expressing cells

1996 • 106 citations

Microarray and Biochemical Analysis of Lovastatin-induced Apoptosis of Squamous Cell Carcinomas

2002 • 98 citations

Multiple cell cycle access to the apoptotic death programme in human neuroblastoma cells

1993 • 82 citations

ZD1839: targeting the epidermal growth factor receptor in cancer therapy

2002 • 58 citations

Role of conformational alteration in the epidermal growth factor receptor (EGFR) function

2000 • 55 citations

Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells

2003 • 34 citations

Phosphorylation of Tyrosine 992, 1068, and 1086 Is Required for Conformational Change of the Human Epidermal Growth Factor Receptor C-Terminal Tail

1999 • 33 citations

Epidermal growth factor receptor structure, regulation, mitogenic signalling and effects of activation.

2001 • 22 citations

Biosynthesis of the epidermal growth factor receptor: Post-translational glycosylation-independent acquisition of tyrosine kinase autophosphorylation activity

1988 • 8 citations