Radiation-induced EGFR-signaling and control of DNA-damage repair

The activation of Akt/PKB signaling pathway and cell survival

2005 • 1,806 citations

CLINICAL CANCER RESEARCH

1956 • 1,729 citations

The protein kinase B/Akt signalling pathway in human malignancy

2002 • 1,609 citations

The EGFR family and its ligands in human cancer

2001 • 1,554 citations

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

2002 • 1,173 citations

Nuclear localization of EGF receptor and its potential new role as a transcription factor

2001 • 1,049 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

2006 • 756 citations

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

2003 • 733 citations

Caveolae/raft-dependent endocytosis

2003 • 722 citations

THE JOURNAL OF BIOLOGICAL CHEMISTRY.

1905 • 551 citations

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

2000 • 549 citations

Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking

2007 • 547 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

2005 • 520 citations

Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase

2005 • 517 citations

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

2002 • 462 citations

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways¹

2003 • 460 citations

Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

1997 • 416 citations

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

2007 • 387 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking

2001 • 386 citations

Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

2002 • 341 citations

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

2001 • 316 citations

Tyrosine phosphorylation controls PCNA function through protein stability

2006 • 306 citations

Base damage and single-strand break repair: Mechanisms and functional significance of short- and long-patch repair subpathways

2006 • 303 citations

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

2004 • 297 citations

Integration of EGFR inhibitors with radiochemotherapy

2006 • 296 citations

Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break

2006 • 284 citations

Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

2005 • 281 citations

Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor–Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

2006 • 268 citations

Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM

2004 • 268 citations

Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity

2003 • 252 citations

The Ras radiation resistance pathway.

2001 • 238 citations

EGFR overexpression and radiation response in glioblastoma multiforme

2001 • 237 citations

Endosomal Transport of ErbB-2: Mechanism for Nuclear Entry of the Cell Surface Receptor

2005 • 233 citations

Nuclear‐cytoplasmic transport of EGFR involves receptor endocytosis, importin β1 and CRM1

2006 • 231 citations

Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells

1998 • 229 citations

Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α

1995 • 213 citations

Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair

2006 • 207 citations

c-erbB-3

2002 • 207 citations

Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.

1994 • 198 citations

Molecular cancer therapeutics

2001 • 189 citations

Co‐regulation of B‐Myb expression by E2F1 and EGF receptor

2005 • 184 citations

EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms

2007 • 176 citations

Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.

2000 • 174 citations

Molecular Consequences of Silencing Mutant K-ras in Pancreatic Cancer Cells: Justification for K-ras–Directed Therapy

2005 • 172 citations

Nuclear localization and possible functions of receptor tyrosine kinases

2003 • 169 citations

Mechanisms controlling EGF receptor endocytosis and degradation

2003 • 169 citations

Epidermal Growth Factor Receptor Exposed to Oxidative Stress Undergoes Src- and Caveolin-1-dependent Perinuclear Trafficking

2006 • 164 citations

Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) Abrogate EGFR-Mediated Radioprotection in Non–Small Cell Lung Carcinoma

2007 • 154 citations

Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation

2005 • 148 citations

Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway

2005 • 146 citations

Epidermal Growth Factor and Ionizing Radiation Up-regulate the DNA Repair GenesXRCC1andERCC1in DU145 and LNCaP Prostate Carcinoma through MAPK Signaling

2003 • 146 citations

The Role of Individual SH2 Domains in Mediating Association of Phospholipase C-γ1 with the Activated EGF Receptor

1999 • 145 citations

Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade.

2002 • 140 citations

The RAS signal transduction pathway and its role in radiation sensitivity

2003 • 140 citations

Nuclear Localization of P185neu Tyrosine Kinase and Its Association with Transcriptional Transactivation

1994 • 132 citations

Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation

2002 • 125 citations

Increased expression of pAKT is associated with radiation resistance in cervical cancer

2006 • 120 citations

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells

1997 • 120 citations

EGFR dependent expression of STAT3 (but not STAT1) in breast cancer

2001 • 120 citations

Internalization of the epidermal growth factor receptor: role in signalling

2001 • 116 citations

The association between Akt activation and resistance to hormone therapy in metastatic breast cancer

2006 • 115 citations

Acquired Resistance to Erlotinib in A-431 Epidermoid Cancer Cells Requires Down-regulation of MMAC1/PTEN and Up-regulation of Phosphorylated Akt

2007 • 113 citations

STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation

2007 • 108 citations

Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity

2007 • 106 citations

Epidermal Growth Factor Receptor Activation under Oxidative Stress Fails to Promote c-Cbl Mediated Down-regulation

2002 • 106 citations

Targeting BRAF in thyroid cancer

2006 • 98 citations

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

2006 • 98 citations

Cytoplasmic Mislocalization of p27Kip1 Protein Is Associated with Constitutive Phosphorylation of Akt or Protein Kinase B and Poor Prognosis in Acute Myelogenous Leukemia

2004 • 98 citations

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance

2005 • 94 citations

Nerve Growth Factor Induces Endothelial Cell Invasion and Cord Formation by Promoting Matrix Metalloproteinase-2 Expression through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and AP-2 Transcription Factor

2007 • 91 citations

MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

2001 • 89 citations

Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS

2004 • 86 citations

The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications

2007 • 86 citations

Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

2007 • 85 citations

Phosphorylation of p27Kip1 at Thr-157 Interferes with Its Association with Importin α during G1 and Prevents Nuclear Re-entry

2004 • 82 citations

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy

2006 • 75 citations

Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation

1996 • 68 citations

K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12

2006 • 65 citations

Survival factors and apoptosis

1998 • 62 citations

Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis

2005 • 60 citations

Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity

2005 • 53 citations

Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis

2006 • 52 citations

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: Differential response of cancer stem cells and nontumourigenic cells?

2007 • 51 citations

A Specific Antagonist of the p110δ Catalytic Component of Phosphatidylinositol 3′-Kinase, IC486068, Enhances Radiation-Induced Tumor Vascular Destruction

2004 • 47 citations

Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.

2003 • 47 citations

Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor–related peptides

1999 • 42 citations

The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies

1985 • 41 citations

Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin

2006 • 38 citations

Ku70/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts

1999 • 37 citations

RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells

2000 • 35 citations

Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo

2005 • 33 citations

Radiotherapy-induced signal transduction

2006 • 29 citations

Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation‐induced DNA base damage

2004 • 18 citations

PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.

2004 • 17 citations

Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase

2004 • 14 citations

Correlation between EGFR gene mutation pattern and Akt phosphorylation in pulmonary adenocarcinomas

2007 • 11 citations

Signal Transduction in Fibroblasts Stably Transformed by [Val12]Ras

1997 • 6 citations

Deleted Work

1955 • 0 citations