Epidermal growth factor receptor-targeted therapy

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

2005 • 3,807 citations

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

2005 • 3,450 citations

ERBB receptors and cancer: the complexity of targeted inhibitors

2005 • 3,200 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Epidermal growth factor receptor (EGFR) signaling in cancer

2005 • 1,852 citations

The EGFR family and its ligands in human cancer

2001 • 1,554 citations

Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer

2004 • 1,206 citations

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

2002 • 1,173 citations

Expression of Epiregulin and Amphiregulin and K-ras Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab

2007 • 1,111 citations

Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

1998 • 1,083 citations

Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry

2005 • 1,081 citations

Nuclear localization of EGF receptor and its potential new role as a transcription factor

2001 • 1,049 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

2005 • 948 citations

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

2000 • 934 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model.

1995 • 791 citations

Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck.

1999 • 707 citations

Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

2005 • 669 citations

Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas

2005 • 652 citations

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

2003 • 647 citations

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

2000 • 549 citations

The EGFR as a target for anticancer therapy—focus on cetuximab

2001 • 540 citations

Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase

2005 • 517 citations

In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.

2000 • 498 citations

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

1983 • 456 citations

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

2006 • 431 citations

Antibody-Dependent Cellular Cytotoxicity Mediated by Cetuximab against Lung Cancer Cell Lines

2007 • 404 citations

Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas.

1999 • 353 citations

Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs

2006 • 345 citations

Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.

2003 • 333 citations

Integration of EGFR inhibitors with radiochemotherapy

2006 • 296 citations

Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.

1999 • 293 citations

Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

2005 • 281 citations

Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments.

2001 • 281 citations

HER1/EGFR Inhibitor-Associated Rash: Future Directions for Management and Investigation Outcomes from the HER1/EGFR Inhibitor Rash Management Forum

2005 • 279 citations

Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma

1996 • 260 citations

Antibody‐dependent cellular cytotoxicity of cetuximab against tumor cells with wild‐type or mutant epidermal growth factor receptor

2007 • 257 citations

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.

1999 • 245 citations

Epidermal Growth Factor Receptor Expression in Pretreatment Biopsies From Head and Neck Squamous Cell Carcinoma As a Predictive Factor for a Benefit From Accelerated Radiation Therapy in a Randomized Controlled Trial

2005 • 245 citations

Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa).

2002 • 245 citations

The type III epidermal growth factor receptor mutation

2001 • 241 citations

Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck

2005 • 236 citations

Molecular Determinants of Cetuximab Efficacy

2005 • 233 citations

Relationship of Epidermal Growth Factor Receptor Expression to ErbB-2 Signaling Activity and Prognosis in Breast Cancer Patients

2005 • 227 citations

Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair

2006 • 207 citations

A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced-EGFR-expressing, non-small cell lung cancer (NSCLC)

2001 • 194 citations

Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results

2004 • 178 citations

EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms

2007 • 176 citations

ZD1839 (‘Iressa’), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model

2002 • 175 citations

Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma—a prospective study

2003 • 174 citations

Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies

2004 • 159 citations

The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

2001 • 157 citations

Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.

2002 • 139 citations

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy

2003 • 127 citations

Aberrant Expression of the Cell Cycle Associated Proteins TP53, MDM2, p21, p27, cdk4, Cyclin D1, RB, and EGFR in Cervical Carcinomas

1999 • 122 citations

Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer

2006 • 117 citations

Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab

2006 • 112 citations

Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery

2002 • 110 citations

Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area

2003 • 106 citations

Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity

2007 • 106 citations

C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors

2002 • 102 citations

Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas

2005 • 98 citations

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

2006 • 98 citations

Rash as a Surrogate Marker for Efficacy of Epidermal Growth Factor Receptor Inhibitors in Lung Cancer

2006 • 97 citations

Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma: An immunohistochemical study

1996 • 96 citations

Targeting Epidermal Growth Factor Receptor in Head and Neck Cancer

2022 • 94 citations

Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix

2005 • 94 citations

Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient.

1991 • 91 citations

The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study

2005 • 90 citations

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

2005 • 88 citations

Prognostic value of epidermal growth factor receptor expression in cervical carcinoma.

1993 • 88 citations

Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance

2004 • 84 citations

EGFR inhibitors: what have we learned from the treatment of lung cancer?

2005 • 81 citations

Phosphorylation, But Not Overexpression, of Epidermal Growth Factor Receptor Is Associated With Poor Prognosis of Non-Small Cell Lung Cancer Patients

2003 • 81 citations

Prognostic Value of EGFR and TGF‐α in Early Laryngeal Cancer Treated With Radiotherapy

1996 • 78 citations

Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas

2000 • 72 citations

ZD1839, AN EPIDERMAL GROWTH FACTOR TYROSINE KINASE INHIBITOR SELECTED FOR CLINICAL DEVELOPMENT

1997 • 70 citations

Randomized phase II – study evaluating EGFR targeting therapy with Cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer – PARC: study protocol [ISRCTN56652283]

2005 • 68 citations

Objective regressions in non-small cell lung cancer patients treated in Phase I trials of oral ZD1839 (IressaTM), a selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR)

2000 • 67 citations

Correlation between Expression of EGFR and the Prognosis of Patients with Cervical Carcinoma

2002 • 62 citations

Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels

2006 • 62 citations

Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation

2007 • 56 citations

The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma.

2007 • 52 citations

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance

2007 • 50 citations

Abnormal Expression of Epidermal Growth Factor Receptor and c-erbB2 in Squamous Cell Carcinoma of the Cervix: Correlation with Human Papillomavirus and Prognosis

2001 • 48 citations

Epidermal growth factor receptor (EGFR) is not related to the prognosis of cervical cancer

1998 • 48 citations

Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis

2004 • 47 citations

Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix

1998 • 46 citations

P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma

2003 • 40 citations

In Vitro Responsiveness of Glioma Cell Lines to Multimodality Treatment With Radiotherapy, Temozolomide, and Epidermal Growth Factor Receptor Inhibition With Cetuximab

2007 • 38 citations

High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC)

2006 • 37 citations

Anti-EGFR–mediated radiosensitization as a result of augmented EGFR expression

2004 • 35 citations

The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma

2005 • 29 citations

The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy

2006 • 28 citations

Ataxia Telangiectasia Mutated Down-regulates Phospho-Extracellular Signal-Regulated Kinase 1/2 via Activation of MKP-1 in Response to Radiation

2006 • 26 citations

ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells

2006 • 19 citations