Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction

The Immunological Synapse

2001 • 987 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

1987 • 327 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity

2000 • 249 citations

Structural variants of human T200 glycoprotein (leukocyte-common antigen).

1987 • 239 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis

1984 • 203 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

Positive and negative regulation of Src-family membrane kinases by CD45

1999 • 184 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

2000 • 155 citations

Characterization of CD45 and CD45R monoclonal antibodies using transfected mouse cell lines that express individual human leukocyte common antigens.

1988 • 140 citations

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

1999 • 137 citations

Cutting Edge: The CD45 Tyrosine Phosphatase Is an Inhibitor of Lck Activity in Thymocytes

1999 • 135 citations

Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady‐state fluorimetric and flow cytometric methods

1984 • 132 citations

The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.

1996 • 111 citations

Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition

1994 • 105 citations

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

1997 • 102 citations

CD45 and Src-family kinases: and now for something completely different

1999 • 87 citations

The Adapter Type Protein CMS/CD2AP Binds to the Proto-oncogenic Protein c-Cbl through a Tyrosine Phosphorylation-regulated Src Homology 3 Domain Interaction

2001 • 86 citations

Evidence for monomeric and dimeric forms of CD45 associated with a 30-kDa phosphorylated protein.

1992 • 85 citations

Expression of the p56^lck Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development

1999 • 76 citations

LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.

1994 • 71 citations

Biochemical Association of CD45 with the T Cell Receptor Complex

1999 • 70 citations

Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase Differentially Regulate Interleukin 2 Secretion and Activation Signal Pathways Involving Vav in T Cells

1995 • 64 citations

Dynamic receptor superstructures at the plasma membrane

1997 • 59 citations

Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.

1991 • 56 citations

The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.

1994 • 56 citations

Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice

2000 • 53 citations

CD45 alternative exon expression in murine and human CD4+ T cell subsets.

1992 • 52 citations

The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice: restoration of pre-TCR function by active p56lck

1999 • 35 citations

The CD45 tyrosine phosphatase regulates Campath-1H (CD52)-induced TCR-dependent signal transduction in human T cells

2000 • 35 citations

Physical Association of CD4 and CD45 in Primary, Resting CD4+T Cells

1997 • 35 citations

Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP

1999 • 24 citations

Lymphocyte signalling : mechanisms, subversion, and manipulation

1997 • 24 citations