The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Human naive and memory T cells

1988 • 793 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells.

1990 • 236 citations

Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes.

1991 • 208 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Regulation of the p59^fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase

1992 • 179 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

1994 • 163 citations

Association of CD2 and CD45 on human T lymphocytes

1990 • 139 citations

Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains

1993 • 138 citations

Molecular associations on the T cell surface correlate with immunological memory

1990 • 130 citations

A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin.

1985 • 119 citations

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.

1990 • 116 citations

Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45

1993 • 112 citations

The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.

1994 • 106 citations

Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition

1994 • 105 citations

B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.

1987 • 105 citations

Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies.

1992 • 87 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

CD45: a leukocyte-specific member of the protein tyrosine phosphatase family

1991 • 76 citations

Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies.

1989 • 72 citations

Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.

1992 • 65 citations

Regulation of the p70^zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase

1995 • 65 citations

Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection.

1994 • 62 citations

Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.

1991 • 56 citations

CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line.

1993 • 54 citations

Differential expression of the alternatively spliced exons of murine CD45 in T_h1 and T_h2 cell clones

1991 • 51 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 46 citations

Heterodimeric, disulfide‐linked α/β T cell receptors in solution

1991 • 46 citations

Developmental expression of CD45 alternate exons in murine T cells. Evidence of additional alternate exon use.

1991 • 38 citations

Association of CD2 and T200 (CD45) in mouse T lymphocytes

1990 • 23 citations

Distinct involvement of CD45 in antigen receptor signalling in CD4⁺ and CD8⁺ primary T cells

1994 • 19 citations