The molecular classification of multiple myeloma

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Diagnosis of multiple cancer types by shrunken centroids of gene expression

2002 • 2,932 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Multiple myeloma

2000 • 2,210 citations

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

2002 • 1,959 citations

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

1999 • 1,410 citations

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

2004 • 1,395 citations

Prognostically Useful Gene-Expression Profiles in Acute Myeloid Leukemia

2004 • 1,353 citations

Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma

2003 • 1,080 citations

Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

2004 • 973 citations

Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes

2004 • 923 citations

Multiple myeloma: evolving genetic events and host interactions

2002 • 815 citations

Single versus Double Autologous Stem-Cell Transplantation for Multiple Myeloma

2004 • 807 citations

Thalidomide and Hematopoietic-Cell Transplantation for Multiple Myeloma

2006 • 749 citations

Genetics and Cytogenetics of Multiple Myeloma

2004 • 698 citations

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

2005 • 687 citations

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

2002 • 655 citations

Clinical and biologic implications of recurrent genomic aberrations in myeloma

2003 • 648 citations

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

2003 • 598 citations

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

2003 • 535 citations

Treatment of multiple myeloma

2003 • 474 citations

Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation

2006 • 466 citations

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

2006 • 429 citations

Hypodiploidy is a major prognostic factor in multiple myeloma

2001 • 394 citations

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

2003 • 388 citations

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

2003 • 374 citations

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

2004 • 365 citations

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy

2005 • 356 citations

Genomic abnormalities in monoclonal gammopathy of undetermined significance

2002 • 351 citations

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

2000 • 328 citations

Biology of Osteoclast Activation in Cancer

2001 • 303 citations

Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

2003 • 238 citations

Jumping Translocations of Chromosome 1q in Multiple Myeloma: Evidence for a Mechanism Involving Decondensation of Pericentromeric Heterochromatin

1998 • 222 citations

Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

2003 • 215 citations

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript

2003 • 194 citations

Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.

2002 • 185 citations

CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma

2003 • 179 citations

Identification of genes regulated by Dexamethasone in multiple myeloma cells using oligonucleotide arrays

2002 • 174 citations

Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays

2002 • 172 citations

Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases

1998 • 170 citations

Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

2003 • 170 citations

Characterization of Nonrandom Chromosomal Gains and Losses in Multiple Myeloma by Comparative Genomic Hybridization

1998 • 153 citations

Long-Term Survival in Multiple Myeloma

1983 • 148 citations

Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease

2003 • 142 citations

Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression

2003 • 134 citations

A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS

2005 • 125 citations

Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation

2003 • 125 citations

A new staging system for multiple myeloma patients based on the Southwest Oncology Group (SWOG) experience

2003 • 119 citations

Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma

2004 • 114 citations

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

2005 • 112 citations

Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization

1997 • 107 citations

Genomic instability in multiple myeloma: Evidence for jumping segmental duplications of chromosome arm 1q

2004 • 107 citations

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma

2004 • 104 citations

Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases

2003 • 99 citations

Predicting long‐term (≥ 5 years) event‐free survival in multiple myeloma patients following planned tandem autotransplants

2002 • 93 citations

Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics

2005 • 93 citations

Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B‐cell lymphoma and multiple myeloma

2001 • 92 citations

Plasma cell myeloma

2001 • 77 citations

Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma

2004 • 75 citations

Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease

2005 • 72 citations

ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma

2005 • 70 citations

Multiple Myeloma

2002 • 60 citations

Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling

2003 • 53 citations

Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma

2005 • 47 citations

Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray

2004 • 45 citations

Thalidomide and CC-5013 in multiple myeloma: the University of Arkansas experience

2003 • 36 citations

Role of osteoblast suppression in multiple myeloma

2006 • 31 citations