Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics

A Simple Sequentially Rejective Multiple Test Procedure

1979 • 20,726 citations

R: A Language for Data Analysis and Graphics

1996 • 9,943 citations

Nonparametric Statistical Methods

1999 • 6,387 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

A statistical method for evaluating systematic relationships

1958 • 4,429 citations

R: A Language for Data Analysis and Graphics

1996 • 4,255 citations

Nonparametric Statistical Methods.

1974 • 2,964 citations

Multiple myeloma: evolving genetic events and host interactions

2002 • 815 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Genetics and Cytogenetics of Multiple Myeloma

2004 • 698 citations

Advances in biology of multiple myeloma: clinical applications

2004 • 606 citations

Hypodiploidy is a major prognostic factor in multiple myeloma

2001 • 394 citations

Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy

2002 • 324 citations

Presence of a p53 Gene Deletion in Patients With Multiple Myeloma Predicts for Short Survival After Conventional-Dose Chemotherapy

1998 • 311 citations

The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma

2003 • 290 citations

Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

2003 • 238 citations

Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma

2003 • 229 citations

Jumping Translocations of Chromosome 1q in Multiple Myeloma: Evidence for a Mechanism Involving Decondensation of Pericentromeric Heterochromatin

1998 • 222 citations

Similarity Analysis by Reciprocal Pairs for Discrete and Continuous Data

1966 • 198 citations

Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.

2002 • 185 citations

Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study

2003 • 168 citations

Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma

2002 • 163 citations

p53 and RAS gene mutations in multiple myeloma.

1992 • 157 citations

Characterization of Nonrandom Chromosomal Gains and Losses in Multiple Myeloma by Comparative Genomic Hybridization

1998 • 153 citations

Non‐random karyotypic evolution in chronic myeloid leukemia

1976 • 145 citations

Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas

2003 • 139 citations

New insights into the pathophysiology of multiple myeloma

2003 • 138 citations

Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression

2003 • 134 citations

Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma

2003 • 130 citations

Distance-Based Reconstruction of Tree Models for Oncogenesis

2000 • 126 citations

Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation

2003 • 125 citations

The (11;14)(q13;q32) Translocation in Multiple Myeloma

2000 • 120 citations

Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma

2004 • 114 citations

Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels

2004 • 112 citations

Cytogenetic Abnormalities Correlate with the Plasma Cell Labeling Index and Extent of Bone Marrow Involvement in Myeloma

1999 • 105 citations

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma

2004 • 104 citations

Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases

2003 • 99 citations

Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma

2001 • 90 citations

Incidence of chromosome numerical changes in multiple myeloma: fluorescence in situ hybridization analysis using 15 chromosome-specific probes.

1996 • 89 citations

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

2002 • 84 citations

Rare occurrence of P53 gene mutations in multiple myeloma

1992 • 77 citations

Molecular aspects of multiple myeloma

2002 • 76 citations

Maximum likelihood estimation of oncogenetic tree models

2004 • 61 citations

Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization

2001 • 60 citations

Value of comparative genomic hybridization and fluorescence in situ hybridization for molecular diagnostics in multiple myeloma

2003 • 46 citations

IL‐4 improves the detection of cytogenetic abnormalities in multiple myeloma and increases the proportion of clonally abnormal metaphases

1998 • 43 citations

Improved cytogenetic analysis of bone marrow plasma cells after cytokine stimulation in multiple myeloma: a report on 46 patients

1993 • 42 citations

Is Flow Cytometric DNA Content Hypodiploidy Prognostic in Multiple Myeloma?

1999 • 40 citations

A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones

1993 • 34 citations

N-ras and p53 gene mutations are very rare events in multiple myeloma.

1995 • 21 citations

Toward the identification of distinct molecular and clinical entities of multiple myeloma using global gene expression profiling

2003 • 18 citations

Detection of 13q abnormalities in multiple myeloma using immunomagnetically selected plasma cells.

2002 • 16 citations