Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts

Calcium's Role in Mechanotransduction during Muscle Development

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Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

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A theory of linear and helical aggregations of macromolecules

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Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

Crystal Structure of Arp2/3 Complex

2001 • 531 citations

Cellular Control of Actin Nucleation

2002 • 507 citations

The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly

1997 • 504 citations

Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation

1998 • 500 citations

Rapid turnover of actin in dendritic spines and its regulation by activity

2002 • 466 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Mechanisms of actin rearrangements mediating platelet activation.

1992 • 413 citations

Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 Complex

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Integrin α2β1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for α2β1-independent platelet reactivity

1995 • 311 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

How is actin polymerization nucleated in vivo?

2001 • 258 citations

Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions

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The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

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The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.

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Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.

1981 • 217 citations

Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking

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Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells

2001 • 190 citations

Reversible binding of actin to gelsolin and profilin in human platelet extracts.

1987 • 162 citations

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.

1996 • 144 citations

Listeria Protein ActA Mimics WASP Family Proteins: It Activates Filament Barbed End Branching by Arp2/3 Complex

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Two Pathways through Cdc42 Couple the N-Formyl Receptor to Actin Nucleation in Permeabilized Human Neutrophils

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Regulation of the actin cycle in vivo by actin filament severing

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Mechanisms of Cold-induced Platelet Actin Assembly

2001 • 100 citations

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

2000 • 90 citations

Comparison of Filamin A-induced Cross-linking and Arp2/3 Complex-mediated Branching on the Mechanics of Actin Filaments

2002 • 82 citations

Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the "barbed" ends of actin filaments but does not sever them.

1986 • 72 citations

Normal Arp2/3 complex activation in platelets lacking WASp

2002 • 71 citations

Gelsolin displaces phalloidin from actin filaments. A new fluorescence method shows that both Ca2+ and Mg2+ affect the rate at which gelsolin severs F-actin

1994 • 64 citations

Gelsolin — evidence for a role in turnover of junction-related actin filaments in Sertoli cells

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Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period

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Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex

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Studying the platelet cytoskeleton in Triton X-100 lysates

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Gelsolin, a Protein That Caps the Barbed Ends and Severs Actin Filaments, Enhances the Actin-Based Motility of Listeria monocytogenes in Host Cells

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Normal Arp2/3 complex activation in platelets lacking WASp

2002 • 9 citations

Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex

2000 • 1 citations