Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

The Platelet Collagen Receptor Glycoprotein VI Is a Member of the Immunoglobulin Superfamily Closely Related to FcαR and the Natural Killer Receptors

1999 • 415 citations

Mechanisms of actin rearrangements mediating platelet activation.

1992 • 413 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Integrin α2β1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for α2β1-independent platelet reactivity

1995 • 311 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

The Platelet Cytoskeleton

1993 • 235 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

Collagen receptor signalling in platelets: extending the role of the ITAM

1998 • 189 citations

LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

1999 • 180 citations

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

1999 • 175 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Phosphatidylinositol 3,4,5-Trisphosphate-dependent Stimulation of Phospholipase C-γ2 Is an Early Key Event in FcγRIIA-mediated Activation of Human Platelets

1998 • 165 citations

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.

1996 • 144 citations

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1998 • 138 citations

D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate

1996 • 135 citations

A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

1999 • 118 citations

Tyrosine Phosphorylation of SLP-76 Is Downstream of Syk following Stimulation of the Collagen Receptor in Platelets

1999 • 110 citations

Lipid Products of Phosphoinositide 3-Kinase Interact with Rac1 GTPase and Stimulate GDP Dissociation

1998 • 103 citations

Protease-Activated G Protein-Coupled Receptors on Human Platelets and Endothelial Cells

1997 • 96 citations

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

2000 • 90 citations

Signaling through CD5 Activates a Pathway Involving Phosphatidylinositol 3-Kinase, Vav, and Rac1 in Human Mature T Lymphocytes

1998 • 79 citations

Evidence that phospholipase C‐γ2 interacts with SLP‐76, Syk, Lyn, LAT and the Fc receptor γ‐chain after stimulation of the collagen receptor glycoprotein VI in human platelets

1999 • 65 citations

Lipid Products of Phosphoinositide 3-Kinase and Phosphatidylinositol 4′,5′-Bisphosphate Are Both Required for ADP-dependent Platelet Spreading

1998 • 59 citations

Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking

1996 • 50 citations

Fc Receptor-mediated Platelet Activation Is Dependent on Phosphatidylinositol 3-Kinase Activation and Involves p120

1999 • 46 citations

Phosphatidylinositol 3′‐kinase and tyrosine‐phosphatase activation positively modulate Convulxin‐induced platelet activation. Comparison with collagen

1999 • 36 citations

Tyrosine Unphosphorylated Platelet SHP-1 Is a Substrate for Calpain

1998 • 29 citations

Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets

1994 • 26 citations

TcRζ/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB

1997 • 15 citations