Lack of Microvessels in Well-Differentiated Regions of Human Head and Neck Squamous Cell Carcinoma A253 Associated with Functional Magnetic Resonance Imaging Detectable Hypoxia, Limited Drug Delivery, and Resistance to Irinotecan Therapy

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cancer Statistics, 2001

2001 • 3,342 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

RARE imaging: A fast imaging method for clinical MR

1986 • 2,031 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

Techniques of autoradiography

1967 • 1,044 citations

Mr contrast due to intravascular magnetic susceptibility perturbations

1995 • 991 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

2001 • 716 citations

Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

2001 • 655 citations

Fractals and cancer.

2000 • 549 citations

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome

1999 • 543 citations

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

2001 • 456 citations

A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy

2001 • 434 citations

Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver

1995 • 296 citations

Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.

2002 • 274 citations

Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

1996 • 225 citations

Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts

2004 • 218 citations

Comparison of the dependence of blood R₂ and R on oxygen saturation at 1.5 and 4.7 Tesla

2002 • 217 citations

How does blood oxygen level‐dependent (BOLD) contrast correlate with oxygen partial pressure (pO₂) inside tumors?

2002 • 211 citations

Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.

2001 • 199 citations

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state

1998 • 179 citations

Drug Resistance in Oncology

1997 • 160 citations

Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.

2002 • 147 citations

The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging

1997 • 130 citations

Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats

1999 • 125 citations

Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs

1997 • 111 citations

Correlation of Magnetic Resonance and Oxygen Microelectrode Measurements of Carbogen-Induced Changes in Tumor Oxygenation

1998 • 105 citations

Synergistic antitumor activity of irinotecan in combination with 5-fluorouracil in rats bearing advanced colorectal cancer: role of drug sequence and dose.

2000 • 104 citations

Clinical pharmacology of camptothecins

1998 • 91 citations

Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts

2004 • 90 citations

Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging

1998 • 83 citations

Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer.

2003 • 79 citations

Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse

1995 • 74 citations

Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas

2004 • 63 citations

Preclinical evaluation of CPT-11 and its active metabolite SN-38.

1996 • 62 citations

Comparison of diffusion‐weighted high‐resolution CBF and spin‐echo BOLD fMRI at 9.4 T

2002 • 61 citations

Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice

1997 • 52 citations

Differences in the vascular patterns of basal and squamous cell skin carcinomas explain their differences in clinical behaviour

2003 • 47 citations

Preclinical MRI experience in imaging angiogenesis.

2000 • 31 citations

An ongoing European organization for research and treatment of cancer crossover trial comparing single-agent paclitaxel and doxorubicin as first- and second-line treatment of advanced breast cancer.

1996 • 13 citations

New drug therapy for squamous carcinoma of the head and neck

1996 • 11 citations

Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38

2002 • 6 citations

Se-(methyl)selenocysteine (MSC) potentiates the antitumor activity of irinotecan against human tumor xenografts and protects against drug induced toxicity

2004 • 3 citations