Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

The Current Status of Camptothecin Analogues as Antitumor Agents

1993 • 614 citations

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

1992 • 456 citations

Irinotecan (CPT-11) High-Dose Escalation Using Intensive High-Dose Loperamide to Control Diarrhea

1994 • 242 citations

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

1991 • 231 citations

Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks.

1994 • 195 citations

Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.

1994 • 170 citations

CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.

1991 • 139 citations

Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma

1994 • 110 citations

Molecular, cellular, and clinical aspects of the pharmacology of 20(S)camptothecin and its derivatives

1995 • 81 citations

Carboxylesterases (EC 3.1.1). Kinetic studies on carboxylesterases

1969 • 77 citations

Human liver carboxylesterase

1974 • 56 citations

Carboxylesterases (EC 3.1.1.). The molecular weight and equivalent weight of pig liver carboxylesterase

1969 • 47 citations

THEORY OF THE TRANSIENT PHASE IN AN ENZYME SYSTEM INVOLVING TWO ENZYME-SUBSTRATE COMPLEXES: THE CASE OF THE FORMATION OF PRODUCTS FROM THE FIRST COMPLEX

1959 • 39 citations

Purification and characterization of two human liver carboxylesterases

1989 • 31 citations