CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

Regulation and Function of NF-κB Transcription Factors in the Immune System

2009 • 2,403 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

The role of TNF superfamily members in T-cell function and diseases

2009 • 846 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells

2004 • 498 citations

Cell-mediated Protection in Influenza Infection

2006 • 452 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

2003 • 353 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

2005 • 232 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand

1999 • 188 citations

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity

2006 • 172 citations

TRAF1 Is a Negative Regulator of TNF Signaling

2001 • 170 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

<scp>TRAF</scp>‐Mediated <scp>TNFR</scp>‐Family Signaling

2002 • 160 citations

ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo

2008 • 157 citations

Addition of a Prominent Epitope Affects Influenza A Virus-Specific CD8+ T Cell Immunodominance Hierarchies When Antigen Is Limiting

2006 • 154 citations

GITR: A Modulator of Immune Response and Inflammation

2009 • 151 citations

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling

2002 • 142 citations

IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival

2006 • 140 citations

The TNF Superfamily

2003 • 119 citations

GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo

2009 • 118 citations

Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling

2006 • 109 citations

A Critical Role for OX40 in T Cell–mediated Immunopathology during Lung Viral Infection

2003 • 108 citations

Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8+ T Cells

2007 • 95 citations

Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease

2009 • 89 citations

Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

2008 • 85 citations

A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival

2006 • 84 citations

Influenza Virus

2001 • 82 citations

Glucocorticoid-Induced TNF Receptor Functions as a Costimulatory Receptor That Promotes Survival in Early Phases of T Cell Activation

2005 • 79 citations

Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation

2009 • 75 citations

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

2008 • 71 citations

In Vivo Kinetics of GITR and GITR Ligand Expression and Their Functional Significance in Regulating Viral Immunopathology

2005 • 69 citations

Glucocorticoid‐induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques

2006 • 68 citations

Tumor Necrosis Factor Receptor (TNFR)-associated Factor 5 Is a Critical Intermediate of Costimulatory Signaling Pathways Triggered by Glucocorticoid-induced TNFR in T Cells

2006 • 60 citations

Glucocorticoid-Induced TNF Receptor, a Costimulatory Receptor on Naive and Activated T Cells, Uses TNF Receptor-Associated Factor 2 in a Novel Fashion as an Inhibitor of NF-κB Activation

2005 • 59 citations

Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection

2004 • 53 citations

Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

2008 • 50 citations

In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

2005 • 37 citations

TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection

2008 • 35 citations

The GITRL–GITR system alters TLR-4 expression on DC during fungal infection

2009 • 16 citations