Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

2003 • 25,662 citations

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

2002 • 9,810 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

European Guidelines for Obesity Management in Adults

2015 • 3,055 citations

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

2006 • 2,996 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Molecular Mechanisms of Human Hypertension

2001 • 1,672 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,435 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,341 citations

Vascular NAD(P)H oxidases: specific features, expression, and regulation

2003 • 1,029 citations

Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases.

2000 • 960 citations

The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

2003 • 691 citations

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

2006 • 663 citations

T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity

2007 • 638 citations

Correction of Arterial Structure and Endothelial Dysfunction in Human Essential Hypertension by the Angiotensin Receptor Antagonist Losartan

2000 • 613 citations

The Prevalence of Prehypertension and Hypertension Among US Adults According to the New Joint National Committee Guidelines

2004 • 566 citations

Role of p47 ^phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II

2002 • 566 citations

Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?

2005 • 478 citations

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

2004 • 441 citations

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

2006 • 432 citations

Adipocytokines - novel link between inflammation and vascular function?

2006 • 427 citations

Immunoregulation in the tissues by γδ T cells

2003 • 412 citations

Rheumatoid Arthritis Is Associated With Increased Aortic Pulse-Wave Velocity, Which Is Reduced by Anti–Tumor Necrosis Factor-α Therapy

2006 • 407 citations

Superoxide Mediates the Actions of Angiotensin II in the Central Nervous System

2002 • 388 citations

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

2003 • 385 citations

Expression and function of Toll-like receptors in T lymphocytes

2006 • 353 citations

Tumor Necrosis Factor-α Induces Endothelial Dysfunction in the Prediabetic Metabolic Syndrome

2006 • 329 citations

Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003

2005 • 316 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

1999 • 305 citations

Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt

2000 • 277 citations

Immunosuppressive Treatment Protects Against Angiotensin II-Induced Renal Damage

2002 • 273 citations

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

2004 • 260 citations

Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats

2002 • 256 citations

Mycophenolate Mofetil Treatment Improves Hypertension in Patients with Psoriasis and Rheumatoid Arthritis

2006 • 220 citations

Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.

1994 • 213 citations

Role of renal NO production in the regulation of medullary blood flow

2003 • 210 citations

Role of Extracellular Superoxide Dismutase in Hypertension

2006 • 205 citations

Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes.

1975 • 203 citations

NAD(P)H Oxidase Mediates Angiotensin II–Induced Vascular Macrophage Infiltration and Medial Hypertrophy

2003 • 181 citations

Requirement for Rac1-Dependent NADPH Oxidase in the Cardiovascular and Dipsogenic Actions of Angiotensin II in the Brain

2004 • 176 citations

Endothelial dysfunction and subendothelial monocyte macrophages in hypertension. Effect of angiotensin converting enzyme inhibition.

1991 • 173 citations

Tissue-tropic effector T cells: generation and targeting opportunities

2006 • 171 citations

Sympathetic innervation of lymph nodes in mice

1984 • 162 citations

Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool

2000 • 160 citations

Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy

1994 • 137 citations

Tumor Necrosis Factor α Blockade Increases Renal Cyp2c23 Expression and Slows the Progression of Renal Damage in Salt-Sensitive Hypertension

2006 • 118 citations

Colocalization of myocardial fibrosis and inflammatory cells in rats.

1994 • 116 citations

Weight Loss in Overweight Adults and the Long-term Risk of Hypertension

2005 • 112 citations

Tubulovascular Nitric Oxide Crosstalk

2002 • 107 citations

Mechanisms Underlying Immunologic States during Pregnancy: Possible Association of the Sympathetic Nervous System

1999 • 99 citations

Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension

2006 • 95 citations

Role of the Multidrug Resistance Protein-1 in Hypertension and Vascular Dysfunction Caused by Angiotensin II

2007 • 94 citations

PERIPHERAL CENTRAL MECHANISMS OF BAROREFLEX RESETTING

1989 • 93 citations

Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22^phox in mice

2004 • 90 citations

Renal Oxidative Stress in Medullary Thick Ascending Limbs Produced by Elevated NaCl and Glucose

2004 • 78 citations

Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes.

1975 • 76 citations

Mechanisms of Pressure Natriuresis

2003 • 69 citations

Disparate Immunoregulatory Potentials for Double-Negative (CD4⁻CD8⁻) αβ and γδ T Cells from Human Patients with Cutaneous Leishmaniasis

2006 • 65 citations

Involvement of IL-17 in Fas ligand-induced inflammation

2004 • 56 citations

Integration and control of circulatory function.

1976 • 53 citations

Loss of the Lysophosphatidylcholine Effector, G2A, Ameliorates Aortic Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice

2006 • 53 citations

Pressure Mediates Angiotensin II–Induced Arterial Hypertrophy and PDGF-A Expression

1998 • 42 citations

A Pressor Response Associated with Drinking in Rats

1977 • 41 citations

Noradrenergic and peptidergic innervation of lymphoid organs in the beluga, Delphinapterus leucas: An anatomical link between the nervous and immune systems

1994 • 39 citations

Development of hypertension in animals with reduced total peripheral resistance.

1992 • 34 citations

Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation

2006 • 32 citations

Antihypertensive effect of neonatal thymectomy in the genetically hypertensive LH rat.

1986 • 31 citations

Systemic administration of autologous, alloactivated helper-enriched lymphocytes to patients with metastatic melanoma of the lung

1986 • 30 citations

Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide

2004 • 25 citations

Peripheral and central mechanisms of baroreflex retseing

1989 • 13 citations