Mitogens trigger a calcium-independent signal for proliferation in phorbol-ester-treated lymphocytes

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Interleukin l and T Cell Activation

1982 • 622 citations

Progress in immunology

1968 • 577 citations

Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.

1983 • 466 citations

Mechanism of T Cell Activation: Role and Functional Relationship of HLA‐DR Antigens and Interleukins

1982 • 244 citations

Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.

1980 • 219 citations

Tumor promoters: Effects on proliferation and differentiation of cells in culture

1978 • 145 citations

Signal requirements for T lymphocyte activation. I. Replacement of macrophage function with phorbol myristic acetate.

1979 • 134 citations

Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D

1978 • 134 citations

Polyclonal activation of human lymphocytes in vitro. I. Characterization of the lymphocyte response to a T cell-independent B cell mitogen.

1980 • 123 citations

Interleukin 2: Biology and biochemistry

1983 • 122 citations

Role of membrane potential in the regulation of lectin‐induced calcium uptake

1984 • 121 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Possible mechanism of phorbol diester-induced maturation of human promyelocytic leukemia cells.

1984 • 110 citations

Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: Induction of competence or incomplete removal?

1981 • 86 citations

A phorbol ester (TPA) can replace macrophages in human lymphocyte cultures stimulated with a mitogen but not with an antigen.

1982 • 73 citations

Signal Requirements for T Lymphocyte Activation

1979 • 63 citations

Volume regulation by human lymphocytes. Identification of differences between the two major lymphocyte subpopulations.

1982 • 57 citations

Permissive role of calcium in the inhibition of T cell mitogenesis by calmodulin antagonists.

1983 • 53 citations

Independent and synergistic thymocyte proliferative activities of PMA and IL 1.

1982 • 53 citations

Monocytes are required to trigger Ca2+ uptake in the proliferative response of human t lymphocytes to staphylococcus aureus protein A.

1984 • 18 citations