A Polymorphism in the Cyclooxygenase 2 Gene as an Inherited Protective Factor Against Myocardial Infarction and Stroke

Applied logistic regression

1990 • 37,000 citations

Inflammation and Atherosclerosis

2002 • 7,456 citations

Applied Logistic Regression.

1990 • 7,187 citations

C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

2000 • 5,760 citations

What's the Relative Risk?

1998 • 3,783 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

The Coxibs, Selective Inhibitors of Cyclooxygenase-2

2001 • 1,563 citations

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

1999 • 1,315 citations

Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins

1994 • 1,261 citations

Aspirin-Resistant Thromboxane Biosynthesis and the Risk of Myocardial Infarction, Stroke, or Cardiovascular Death in Patients at High Risk for Cardiovascular Events

2002 • 1,054 citations

Platelet-Active Drugs

2001 • 993 citations

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

1996 • 851 citations

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension

1998 • 771 citations

Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study

1995 • 689 citations

Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects

2004 • 676 citations

Macrophages and atherosclerotic plaque stability

1996 • 474 citations

C‐Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

2001 • 440 citations

The Receptor RAGE as a Progression Factor Amplifying Arachidonate-Dependent Inflammatory and Proteolytic Response in Human Atherosclerotic Plaques

2003 • 367 citations

Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E ₂ -Dependent Plaque Instability

2001 • 349 citations

Common Promoter Variant in Cyclooxygenase-2 Represses Gene Expression

2002 • 329 citations

Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

2001 • 289 citations

Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

2001 • 237 citations

Oxidant Stress and Aspirin-Insensitive Thromboxane Biosynthesis in Severe Unstable Angina

2000 • 227 citations

Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

2001 • 217 citations

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man

1982 • 208 citations

Differential Suppression of Thromboxane Biosynthesis by Indobufen and Aspirin in Patients With Unstable Angina

1997 • 175 citations

Report of Final Mortality Statistics, 1995

1997 • 153 citations

Suppression of the Functionally Coupled Cyclooxygenase-2/Prostaglandin E Synthase as a Basis of Simvastatin-Dependent Plaque Stabilization in Humans

2003 • 145 citations

Blockade of the Angiotensin II Type 1 Receptor Stabilizes Atherosclerotic Plaques in Humans by Inhibiting Prostaglandin E ₂ –Dependent Matrix Metalloproteinase Activity

2004 • 140 citations

Selective cyclooxygenase-2 inhibition by nimesulide in man.

1998 • 137 citations

Cyclooxygenase-2 Expression and Inhibition in Atherothrombosis

2003 • 123 citations

Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F ₂ -Isoprostane Formation in Hypercholesterolemic Subjects

2002 • 116 citations

Report of final mortality statistics, 1994

1996 • 113 citations

Angiotensin-Converting Enzyme Inhibitor Prevents Age-Related Endothelial Dysfunction

2000 • 68 citations

Specific Interaction of Oxidized Low-Density Lipoprotein With Macrophage-Derived Foam Cells Isolated From Rabbit Atherosclerotic Lesions

1999 • 34 citations

Modulation of Aspirin-Insensitive Eicosanoid Biosynthesis by 6-Methylprednisolone in Unstable Angina

2003 • 32 citations

Cyclooxygenase-2 Polymorphism

2002 • 28 citations