Common Promoter Variant in Cyclooxygenase-2 Represses Gene Expression

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Production of C-reactive protein and risk of coronary events in stable and unstable angina

1997 • 1,515 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

The Sp-family of transcription factors

1999 • 1,098 citations

Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease

1998 • 987 citations

The −308 tumor necrosis factor-α promoter polymorphism effects transcription

1997 • 868 citations

Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis^a

2000 • 828 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Why there are two cyclooxygenase isozymes

2001 • 612 citations

Prognostic Influence of Increased Fibrinogen and C-Reactive Protein Levels in Unstable Coronary Artery Disease

1997 • 529 citations

Structure of the human cyclo-oxygenase-2 gene

1994 • 488 citations

Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

2001 • 408 citations

The interleukin-6 −174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men

2001 • 406 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Characterization of the Genomic Structure, Chromosomal Location and Promoter of Human Prostaglandin H Synthase-2 Gene

1994 • 272 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Regulation of Macrophage Cytokine Production by Prostaglandin E2

1997 • 188 citations

Lipid-Mediated Enhancement of Transfection by a Nonviral Integrin-Targeting Vector

1998 • 182 citations

A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness

1996 • 177 citations

Electrophoresis for Genotyping: Microtiter Array Diagonal Gel Electrophoresis on Horizontal Polyacrylamide Gels, Hydrolink, or Agarose

1994 • 170 citations

Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive protein concentrations

1999 • 114 citations

Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium

2000 • 111 citations

Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute‐phase protein responses in patients undergoing cardiac surgery

1998 • 108 citations

Functional characterization of cyclooxygenase-2 polymorphisms.

2001 • 102 citations

Colon cancer prevention by NSAIDs: what is the mechanism of action?

2002 • 89 citations

Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome.

1990 • 79 citations

Progress in the Treatment of Rheumatoid Arthritis

2001 • 78 citations

Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein

2001 • 72 citations

Transgenic mice expressing rabbit C-reactive protein exhibit diminished chemotactic factor-induced alveolitis.

1996 • 67 citations

Procalcitonin as a Marker of Systemic Inflammation After Conventional or Minimally Invasive Coronary Artery Bypass Grafting

1998 • 50 citations

Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-β response element

1997 • 43 citations

The Effect of Fibrinogen Genotype on Fibrinogen Levels after Strenuous Physical Exercise

2002 • 35 citations

Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large Swiss familial adenomatous polyposis kindred

2000 • 27 citations

Human lymphocytes synthesize C-reactive protein

1986 • 23 citations

Transcription Factors NF‐IL6 and APRF Involved in gp130‐mediated Signaling Pathwaya

1995 • 23 citations

Differential transcriptional regulation of the human thrombin receptor gene by the Sp family of transcription factors in human endothelial cells

1998 • 22 citations

Prostaglandins Cause An Increase in Serum Acute-Phase Proteins in Man, Which is Diminished in Systemic Sclerosis

1984 • 21 citations

Use of acute phase protein changes to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid) on the inflammation process induced by limited plastic surgery.

1985 • 2 citations