High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC)

Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer

2003 • 2,874 citations

Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer

2003 • 2,522 citations

Global cancer statistics in the year 2000

2001 • 2,471 citations

EGFR and cancer prognosis

2001 • 2,068 citations

The new World Health Organization classification of lung tumours

2001 • 1,131 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function

1999 • 633 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.

2000 • 498 citations

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

1995 • 465 citations

Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials

1997 • 456 citations

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.

2001 • 455 citations

Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy

2001 • 452 citations

Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression.

1997 • 404 citations

Lung cancer : principles and practice

1996 • 345 citations

Immunocytochemical markers in stage I lung cancer: relevance to prognosis.

1997 • 313 citations

Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor

1998 • 304 citations

A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.

1995 • 300 citations

Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer

2003 • 282 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

The type III epidermal growth factor receptor mutation

2001 • 241 citations

Expression of Activated Epidermal Growth Factor Receptors, Ras-Guanosine Triphosphate, and Mitogen-activated Protein Kinase in Human Glioblastoma Multiforme Specimens

1999 • 230 citations

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

2001 • 204 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)

1997 • 186 citations

Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway

1996 • 175 citations

A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer

1996 • 152 citations

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.

1994 • 144 citations

Novel Targets for Lung Cancer Therapy: Part I

2002 • 141 citations

Glycosylation-induced Conformational Modification Positively Regulates Receptor-Receptor Association

2001 • 137 citations

Synchronous Overexpression of Epidermal Growth Factor Receptor and HER2- neu Protein Is a Predictor of Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer

2004 • 136 citations

Expression of constitutively activated EGFRvlll in non‐small cell lung cancer

2003 • 129 citations

Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype

1995 • 123 citations

Increased epidermal growth factor receptor expression in metaplastic bronchial epithelium.

1996 • 103 citations

Phosphorylation, But Not Overexpression, of Epidermal Growth Factor Receptor Is Associated With Poor Prognosis of Non-Small Cell Lung Cancer Patients

2003 • 81 citations

Mutant Epidermal Growth Factor Receptors as Targets for Cancer Therapy

2002 • 70 citations

Enzyme-linked immunosorbent assay of epidermal growth factor receptor in lung cancer: comparisons with immunohistochemistry, clinicopathological features and prognosis

1998 • 45 citations

Immunohistochemical typing of non-small cell lung cancer on cryostat sections: correlation with clinical parameters and prognosis

2003 • 31 citations

Intracellular expression of the truncated extracellular domain of c-erbB-3/HER3

2001 • 22 citations

Ongoing and future trials of biologic therapies in lung cancer

2003 • 20 citations

Characterisation and predictive value of epidermal growth factor receptor status using quantitative real-time PCR combined with immunohistochemistry on non-small cell lung cancer specimens

2003 • 9 citations