Kinetics of B Cell Receptor Signaling in Human B Cell Subsets Mapped by Phosphospecific Flow Cytometry

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

The p53 pathway: positive and negative feedback loops

2005 • 1,899 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Hydrogen peroxide as second messenger in lymphocyte activation

2002 • 760 citations

Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells

2004 • 692 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Regulation of B-cell fate by antigen-receptor signals

2002 • 619 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events

2003 • 553 citations

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

2004 • 552 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR

1997 • 440 citations

Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

2004 • 335 citations

Mapping normal and cancer cell signalling networks: towards single-cell proteomics

2006 • 317 citations

Contribution of Receptor Editing to the Antibody Repertoire

2001 • 312 citations

Amplification of B Cell Antigen Receptor Signaling by a Syk/ITAM Positive Feedback Loop

2002 • 312 citations

The functional Interactions Between the MAPK and p53 Signaling Pathways

2004 • 296 citations

Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

2002 • 282 citations

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.

1995 • 264 citations

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

2005 • 261 citations

The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer

2005 • 217 citations

The Strength of Receptor Signaling Is Centrally Controlled through a Cooperative Loop between Ca2+ and an Oxidant Signal

2005 • 204 citations

Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

2002 • 202 citations

CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction

2005 • 180 citations

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

1999 • 175 citations

Pre-B Cell Receptor Signaling Mediates Selective Response to IL-7 at the Pro-B to Pre-B Cell Transition via an ERK/MAP Kinase-Dependent Pathway

2001 • 172 citations

A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor

2002 • 171 citations

RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling

2005 • 154 citations

Function of Bruton’s Tyrosine Kinase during B Cell Development Is Partially Independent of Its Catalytic Activity

2003 • 106 citations

Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells

2004 • 94 citations

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

1994 • 87 citations

Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection

2002 • 64 citations

Isotype Control of B Cell Signaling

2003 • 12 citations

Isotype Control of B Cell Signaling

2003 • 2 citations