Molecular motions within the pore of voltage-dependent sodium channels

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

1971 • 751 citations

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

1992 • 708 citations

Additivity of mutational effects in proteins

1990 • 652 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

1991 • 460 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

1996 • 254 citations

Global Flexibility in a Sensory Receptor: a Site-Directed Cross-Linking Approach

1987 • 249 citations

Thermal motions of surface α-helices in the d-galactose chemosensory receptor

1992 • 238 citations

Conformations of disulfide bridges in proteins

1990 • 195 citations

Molecular basis of proton block of L-type Ca2+ channels.

1996 • 147 citations

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1996 • 111 citations

Depth Asymmetries of the Pore-Lining Segments of the Na+ Channel Revealed by Cysteine Mutagenesis

1996 • 107 citations

Transmembrane signaling by the aspartate receptor: Engineered disulfides reveal static regions of the subunit interface

1995 • 94 citations

Characterization of the high‐affinity Ca2+ binding sites in the L‐type Ca2+ channel pore in rat phaeochromocytoma cells.

1993 • 94 citations

Interactions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry

1996 • 92 citations

THE PENETRATION OF SOME CATIONS INTO MUSCLE

1959 • 92 citations

A mutation in the pore of the sodium channel alters gating

1995 • 77 citations

Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.

1996 • 70 citations

Large Amplitude Twisting Motions of an Interdomain Hinge: A Disulfide Trapping Study of the Galactose-Glucose Binding Protein

1995 • 69 citations

Altered Ionic Selectivity of the Sodium Channel Revealed by Cysteine Mutations within the Pore

1997 • 69 citations

Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.

1996 • 55 citations

Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis

1997 • 53 citations

Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification

1997 • 46 citations

Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore

1997 • 45 citations

Structural models of Na+, Ca2+, and K+ channels.

1995 • 40 citations

A method for the site-directed mono- and multi-mutagenesis of double-stranded DNA

1993 • 26 citations

Oxidation of an engineered pore cysteine locks a voltage-gated K+ channel in a nonconducting state

1996 • 12 citations