On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

The action of calcium on the electrical properties of squid axons

1957 • 1,853 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS

1995 • 941 citations

Mechanism of ion permeation through calcium channels

1984 • 850 citations

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

1971 • 751 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH

1975 • 599 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels

1983 • 535 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

1991 • 460 citations

Structure of pentameric human serum amyloid P component

1994 • 459 citations

Structural Aspects of Metal Liganding to Functional Groups in Proteins

1991 • 454 citations

Ionic selectivity, saturation, and block in sodium channels. A four-barrier model.

1975 • 400 citations

Voltage clamp experiments on internally perfused giant axons.

1965 • 400 citations

Ion‐concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction.

1979 • 394 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

Molecular Tuning of Ion Binding to Calcium Signaling Proteins

1994 • 370 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

Voltage‐clamp experiments in normal and denervated mammalian skeletal muscle fibres.

1980 • 277 citations

Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions

1995 • 277 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

Atomic structure of single-stranded DNA bacteriophage ΦX174 and its functional implications

1992 • 248 citations

Calcium-Binding Sites in Proteins: A Structural Perspective

1991 • 247 citations

Thrombin is a sodium ion activated enzyme

1992 • 232 citations

The Ca channel in skeletal muscle is a large pore.

1985 • 219 citations

Direct measurement of proton transfer rates to a group controlling the dihydropyridine-sensitive Ca2+ channel

1987 • 201 citations

Dialkylglycine Decarboxylase Structure: Bifunctional Active Site and Alkali Metal Sites

1993 • 189 citations

INTERPRETATION OF BIOLOGICAL ION CHANNEL FLUX DATA—Reaction-Rate versus Continuum Theory

1986 • 188 citations

Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel

1993 • 173 citations

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin.

1995 • 165 citations

Calcium inward currents in internally perfused giant axons

1973 • 165 citations

Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels

1984 • 155 citations

Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.

1993 • 148 citations

Structural determinants of ion selectivity in brain calcium channel

1993 • 147 citations

PERMEATION IN POTASSIUM CHANNELS: Implications for Channel Structure

1987 • 123 citations

Crystal structure of tandem type III fiibronectin domains from drosophila neuroglian at 2.0 å

1994 • 104 citations

Fluctuations of barrier structure in ionic channels

1980 • 102 citations

Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels.

1991 • 82 citations

Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.

1992 • 76 citations

Glutamate substitution in repeat IV alters divalent and monovalent cation permeation in the heart Ca2+ channel

1995 • 74 citations

Ionic selectivity of the sodium channel of frog skeletal muscle.

1976 • 71 citations

Calcium block of guinea‐pig heart sodium channels with and without modification by the piperazinylindole DPI 201‐106.

1988 • 66 citations

Differential contribution by conserved glutamate residues to an ion‐selectivity site in the L‐type Ca²⁺ channel pore

1993 • 63 citations

Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site

1991 • 60 citations

Potassium Selectivity in Proteins: Oxygen Cage or π in the Face?

1993 • 59 citations

[4] Kinetics of ion movement mediated by carriers and channels

1989 • 57 citations

An Alkali Metal Ion Size-Dependent Switch in the Active Site Structure of Dialkylglycine Decarboxylase

1994 • 54 citations

Effects of external protons on single cardiac sodium channels from guinea pig ventricular myocytes.

1991 • 52 citations

Specificity for block by saxitoxin and divalent cations at a residue which determines sensitivity of sodium channel subtypes to guanidinium toxins.

1995 • 51 citations

Ion permeation, divalent ion block, and chemical modification of single sodium channels. Description by single- and double-occupancy rate- theory models [published erratum appears in J Gen Physiol 1994 May;103(5):937]

1994 • 48 citations

Proton block of rat brain sodium channels. Evidence for two proton binding sites and multiple occupancy.

1993 • 41 citations

Zn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics.

1991 • 41 citations

Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore

1992 • 41 citations

Patch recordings from the electrocytes of Electrophorus electricus. Na currents and PNa/PK variability.

1991 • 40 citations

The permeability of the sodium channel in Myxicola to the alkali cations.

1976 • 39 citations

MOLECULAR PROPERTIES OF ION PERMEATION THROUGH SODIUM CHANNELS

1987 • 38 citations

Modulation of sodium channel gating by external divalent cations: differential effects on opening and closing rates

1990 • 35 citations

Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel

1994 • 28 citations

Ion conduction in substates of the batrachotoxin-modified Na+ channel from toad skeletal muscle

1993 • 28 citations

Zinc inhibition of chloride efflux from skeletal muscle ofRana pipiens and its modification by external pH and chloride activity

1990 • 12 citations